NODAL

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Nodal homolog (mouse)
Identifiers
Symbols NODAL; MGC138230
External IDs OMIM: 601265 MGI: 97359 HomoloGene: 8417
Orthologs
Human Mouse
Entrez 4838 18119
Ensembl ENSG00000156574 ENSMUSG00000037171
Uniprot Q96S42 A0PK81
Refseq NM_018055 (mRNA)
NP_060525 (protein)		 NM_013611 (mRNA)
NP_038639 (protein)
Location Chr 10: 71.86 - 71.87 Mb Chr 10: 60.81 - 60.82 Mb
Pubmed search [1] [2]

Nodal homolog (mouse), also known as NODAL, is a human gene.12

The protein encoded by this gene is a member of the TGF beta superfamily. Studies of the mouse counterpart suggested that this gene may be essential for mesoderm formation and subsequent organization of axial structures in early embryonic development.2

Like many other members of this superfamily, it is involved in cell differentiation. Nodal plays an essential role in mesoderm formation and axis specification. Nodal null mice die shortly after gastrulation.3

References

  1. ^ Gebbia M, Ferrero GB, Pilia G, Bassi MT, Aylsworth A, Penman-Splitt M, Bird LM, Bamforth JS, Burn J, Schlessinger D, Nelson DL, Casey B (November 1997). "X-linked situs abnormalities result from mutations in ZIC3". Nat. Genet. 17 (3): 305–8. doi:10.1038/ng1197-305. PMID 9354794. 
  2. ^ a b "Entrez Gene: NODAL nodal homolog (mouse)".
  3. ^ Reissmann E, Jörnvall H, Blokzijl A, et al (August 2001). "The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development". Genes Dev. 15 (15): 2010–22. doi:10.1101/gad.201801. PMID 11485994. 

Further reading

  • Postovit LM, Seftor EA, Seftor RE, Hendrix MJ (2007). "Targeting Nodal in malignant melanoma cells.". Expert Opin. Ther. Targets 11 (4): 497–505. doi:10.1517/14728222.11.4.497. PMID 17373879. 
  • Zhou X, Sasaki H, Lowe L, et al. (1993). "Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation.". Nature 361 (6412): 543–7. doi:10.1038/361543a0. PMID 8429908. 
  • Gebbia M, Ferrero GB, Pilia G, et al. (1997). "X-linked situs abnormalities result from mutations in ZIC3.". Nat. Genet. 17 (3): 305–8. doi:10.1038/ng1197-305. PMID 9354794. 
  • Yan YT, Liu JJ, Luo Y, et al. (2002). "Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway.". Mol. Cell. Biol. 22 (13): 4439–49. PMID 12052855. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Roberts HJ, Hu S, Qiu Q, et al. (2003). "Identification of novel isoforms of activin receptor-like kinase 7 (ALK7) generated by alternative splicing and expression of ALK7 and its ligand, Nodal, in human placenta.". Biol. Reprod. 68 (5): 1719–26. doi:10.1095/biolreprod.102.013045. PMID 12606401. 
  • Munir S, Xu G, Wu Y, et al. (2004). "Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells.". J. Biol. Chem. 279 (30): 31277–86. doi:10.1074/jbc.M400641200. PMID 15150278. 
  • Haffner C, Frauli M, Topp S, et al. (2005). "Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.". EMBO J. 23 (15): 3041–50. doi:10.1038/sj.emboj.7600307. PMID 15257293. 
  • Besser D (2004). "Expression of nodal, lefty-a, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3.". J. Biol. Chem. 279 (43): 45076–84. doi:10.1074/jbc.M404979200. PMID 15308665. 
  • Bamforth SD, Bragança J, Farthing CR, et al. (2004). "Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway.". Nat. Genet. 36 (11): 1189–96. doi:10.1038/ng1446. PMID 15475956. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Vallier L, Reynolds D, Pedersen RA (2005). "Nodal inhibits differentiation of human embryonic stem cells along the neuroectodermal default pathway.". Dev. Biol. 275 (2): 403–21. doi:10.1016/j.ydbio.2004.08.031. PMID 15501227. 
  • Hart AH, Willson TA, Wong M, et al. (2005). "Transcriptional regulation of the homeobox gene Mixl1 by TGF-beta and FoxH1.". Biochem. Biophys. Res. Commun. 333 (4): 1361–9. doi:10.1016/j.bbrc.2005.06.044. PMID 15982639. 
  • Vallier L, Alexander M, Pedersen RA (2006). "Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells.". J. Cell. Sci. 118 (Pt 19): 4495–509. doi:10.1242/jcs.02553. PMID 16179608. 

External links

v • d • e
Cell signaling: TGF beta signaling pathway
TGF beta superfamily of ligands
TGF beta receptors
(Activin, BMP)
Transducers/SMAD
Ligand inhibitors
Coreceptors
Other
 This article on a gene on chromosome 10 is a stub. You can help Wikipedia by expanding it.

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