NOS1

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Nitric oxide synthase 1 (neuronal)
PDB rendering based on 1b8q.
Available structures: 1b8q, 1f20, 1k2r, 1k2s, 1k2t, 1k2u, 1lzx, 1lzz, 1m00, 1mmv, 1mmw, 1om4, 1om5, 1p6h, 1p6i, 1p6j, 1p6k, 1qau, 1qav, 1qw6, 1qwc, 1rs6, 1rs7, 1tll, 1vag, 1zvi, 1zvl, 1zzq, 1zzr, 1zzu, 2g6h, 2g6i, 2g6j, 2g6k, 2g6l, 2g6m, 2g6n, 2hx3, 2hx4
Identifiers
Symbols NOS1; IHPS1; NOS
External IDs OMIM: 163731 MGI: 97360 HomoloGene: 37327
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4842 18125
Ensembl ENSG00000089250 ENSMUSG00000029361
Uniprot P29475 Q9JJ30
Refseq NM_000620 (mRNA)
NP_000611 (protein)		 XM_992536 (mRNA)
XP_997630 (protein)
Location Chr 12: 116.14 - 116.28 Mb Chr 5: 118.1 - 118.22 Mb
Pubmed search [1] [2]

Nitric oxide synthase 1 (neuronal), also known as NOS1, is a human gene.

The gene is located on chromosome 12. It has been implicated in asthma,[1][2] schizophrenia[3][4] and so-called restless leg syndrome.[5] It has also been investigated with respect to bipolar disorder.[6]

See also

Reference

  1. ^ H. Grasemann, C. N. Yandava & J. M. Drazen (December 1999). "Neuronal NO synthase (NOS1) is a major candidate gene for asthma". Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 29 Suppl 4: 39–31. PMID 10641565. 
  2. ^ T. F. Leung, E. K. H. Liu, N. L. S. Tang, F. W. S. Ko, C. Y. Li, C. W. K. Lam & G. W. K. Wong (October 2005). "Nitric oxide synthase polymorphisms and asthma phenotypes in Chinese children". Clinical and Experimental Allergy 35 (10): 1288–1284. doi:10.1111/j.1365-2222.2005.02342.x. PMID 16238787. 
  3. ^ T. Shinkai, O. Ohmori, H. Hori & J. Nakamura (2002). "Allelic association of the neuronal nitric oxide synthase (NOS1) gene with schizophrenia". Molecular Psychiatry 7 (6): 560–563. doi:10.1038/sj.mp.4001041. PMID 12140778. 
  4. ^ A. Reif, S. Herterich, A. Strobel, A.-C. Ehlis, D. Saur, C. P. Jacob, T. Wienker, T. Topner, S. Fritzen, U. Walter, A. Schmitt, A. J. Fallgatter & K.-P. Lesch (March 2006). "A neuronal nitric oxide synthase (NOS-I) haplotype associated with schizophrenia modifies prefrontal cortex function". Molecular Psychiatry 11 (3): 286–280. doi:10.1038/sj.mp.4001779. PMID 16389274. 
  5. ^ Juliane Winkelmann, Peter Lichtner, Barbara Schormair, Manfred Uhr, Stephanie Hauk, Karin Stiasny-Kolster, Claudia Trenkwalder, Walter Paulus, Ines Peglau, Ilonka Eisensehr, Thomas Illig, H.-Erich Wichmann, Hildegard Pfister, Jelena Golic, Thomas Bettecken, Benno Putz, Florian Holsboer, Thomas Meitinger & Bertram Muller-Myhsok (February 2008). "Variants in the neuronal nitric oxide synthase (nNOS, NOS1) gene are associated with restless legs syndrome". Movement Disorders 23 (3): 350–358. doi:10.1002/mds.21647. PMID 18058820. 
  6. ^ H. N. Buttenschon, O. Mors, H. Ewald, A. McQuillin, G. Kalsi, J. Lawrence, H. Gurling & T. A. Kruse (January 2004). "No association between a neuronal nitric oxide synthase (NOS1) gene polymorphism on chromosome 12q24 and bipolar disorder". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 124B (1): 73–75. doi:10.1002/ajmg.b.20040. PMID 14681919. 

Further reading

  • Miyagoe-Suzuki Y, Takeda SI (2002). "Association of neuronal nitric oxide synthase (nNOS) with alpha1-syntrophin at the sarcolemma.". Microsc. Res. Tech. 55 (3): 164–70. doi:10.1002/jemt.1167. PMID 11747091. 
  • Waddington SN (2002). "Arginase in glomerulonephritis.". Kidney Int. 61 (3): 876–81. doi:10.1046/j.1523-1755.2002.00236.x. PMID 11849441. 
  • Rotilio G, Aquilano K, Ciriolo MR (2004). "Interplay of Cu,Zn superoxide dismutase and nitric oxide synthase in neurodegenerative processes.". IUBMB Life 55 (10-11): 629–34. PMID 14711010. 
 This article on a gene on chromosome 12 is a stub. You can help Wikipedia by expanding it.
v • d • e
Oxidoreductases: dioxygenases, including steroid hydroxylases (EC 1.14)
1.14.11 - 2-oxoglutarate
1.14.13 - NADH or NADPH
1.14.14 - reduced flavin or flavoprotein
1.14.15 - reduced iron-sulfur protein
1.14.16 - reduced pteridine
1.14.17 - reduced ascorbate
1.14.18-19 - other
1.14.99 - miscellaneous
v • d • e
Metabolism: amino acid metabolism - neurotransmitter enzymes
histidine→histamine
tyrosine→dopamine→epinephrine
glutamate→GABA
tryptophan→serotonin→melatonin
arginine→NO
choline→Acetylcholine
see also intermediates


Wikipedia content modification information:

  • This page was last modified on 9 September 2008, at 20:45.

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