Nialamide

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Nialamide
Systematic (IUPAC) name
N-benzyl-3-(N'-pyridin-4-ylcarbonylhydrazino) -propanamide
Identifiers
CAS number 51-12-7
ATC code N06AF02
PubChem 4472
Chemical data
Formula C16H18N4O2 
Mol. mass 298.34 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion Renal[1]
Therapeutic considerations
Pregnancy cat.

?
Legal status

℞ Prescription only
Routes Oral, intramuscular,[2] intravenous[3]

Nialamide was one of the first MAOI (monoamine oxidase inhibitor) antidepressants. It is chemically related to iproniazide, another MAOI derived from isonicotinic acid.

Contents

Indications

Depression

Nialamide is effective for depression characterized by anergic symptoms,[4] endogenous depression,[5] and reactive depression.[6]

Other

Nialamide is sometimes used in the treatment of trigeminal neuralgia. It has also been studied for alcoholism,[7] dermatomally distributed vitiligo,[8] irregular menstruation,[9] angina,[10] cerebrovascular disorders,[11] and the prevention of streptomycin-induced deafness.[12]

Adverse effects

Adverse effects of nialamide include euphoria, psychomotor agitation, insomnia, anxiety, headache, vertigo, tremor, hyperreflexia, manic state, arterial hypotension, orthostatic hypotension, arterial hypertension, palpitations, hyperhidrosis, dry mouth, nausea, vomiting, epigastric pain, constipation, vision problems, retrobulbar optic neuritis, polyneuritis, weight gain, acute cardiac insufficiency, tachycardia, peripheral neuropathy, jaundice, hepatomegaly, hyperbilirubinemia, urinary retention, elevated transaminases, hepatitis, hepatocellular insufficiency, cutaneous eruption, impotence, and delayed ejaculation.[1]

Tradenames

Nialamide is sold under Psicodisten, Niaquitil, Nialamid, Niamidal, Niamide, Novazid, Nuredal, Niamid (Italy, Belgium, Netherlands, England, United States),[13] Niazin, Nyazin, Surgex (Italy),[1] Mygal, Delmoneurina, Isalizina (Italy),[1] Espril (Italy),[1] and Nyezin.[14]

References and End Notes

  1. ^ a b c d e "NIALAMIDE". BIAM Database (2001). Retrieved on 2005-08-27.
  2. ^ Benady DR, Clein LJ, Pare CM (1965). "Intramuscular nialamide in intractable depression". Diseases of the Nervous System 26 (12): 792–4. 
  3. ^ Oules J, Cabazon (1964). "[Treatment Of Depressive States With Intravenous Niamide.]". Toulouse Medical 65 (1): 1298–302. PMID 14272189. 
  4. ^ Vaisberg M, McGahee CL, Radinger N, Saunders JC (1959). "Nialamide for the treatment of anergy and depression". Diseases of the Nervous System 20 (Supplemental): 22–5. PMID 13840714. 
  5. ^ Van Reeth PC, Bloch C (1960). "[Treatment of endogenous depressions by a new inhibitor of monoamine oxidase: nialamide.]". Acta Neurologica Belgica 60 (1): 320–7. PMID 13841128. 
  6. ^ Cormary M (1966). "[Use of parenteral nialamide in the treatment of reactive or neurotic depressive states]". Lyon Medical 215 (15): 1051–62. PMID 5930244. 
  7. ^ Bobrov AE, Shurygin AN, Krasil'nikov SB (1991). "[Effectiveness of combined use of monoamine oxidase inhibitors and psychotherapy in the treatment of chronic alcoholism]". Zhurnal Nevropatologii i Psikhiatrii Imeni SS Korsakova. 91 (2): 79–83. PMID 1647635. 
  8. ^ Koga M (1977). "Vitiligo: a new classification and therapy". British Journal of Dermatology 97 (3): 255–61. doi:10.1111/j.1365-2133.1977.tb15180.x. PMID 921895. 
  9. ^ Gautray JP, Jolivet A (1976). "[Neuroendocrine investigation and therapy of the menstrual cycle disorders (author's transl)(proceedings)]". Annales d'Endocrinologie 37 (4): 293–4. PMID 1022189. 
  10. ^ Barats SS, Oranskii IE, Kartashova DI, Gorovater EN (1976). "[Comparative clinico-physiological study of the effect of several MAO inhibitors in stenocardia]". Kardiologiia 16 (3): 138–40. PMID 1021625. 
  11. ^ Mirzoian RS (1975). "[Prevention of cerebrovascular disorders with adrenergic substances]". Biulleten' Eksperimental'noi Biologii i Meditsiny 80 (11): 50–3. PMID 1218262. 
  12. ^ Semczuk B, Klonowski S, Golabek W (1974). "The protective effect of niamid on hearing in patients treated with large doses of streptomycin". Annales Universitatis Mariae Curie-Sklodowska Sectio D: Medicina 29 (1): 193–7. PMID 4467804. 
  13. ^ Anonymous (2001). "NIALAMIDE". Antidepresseurs. BIAM. Retrieved on 2005-08-27.
  14. ^ "SID 35970 -- PubChem Substance Summary - Depositor-Supplied Synonyms: All". Retrieved on 2005-09-25. National Center for Biotechnology Information.
v • d • e
Psychoanaleptics: antidepressants (N06A)
MAOIs
RIs
SSREs
AAs

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  • This page was last modified on 23 June 2008, at 19:22.

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