This MedLibrary.org supplementary page on Nicotinate N-methyltransferase is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:
Related Sponsors
In enzymology, a nicotinate N-methyltransferase (EC 2.1.1.7) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + nicotinate
S-adenosyl-L-homocysteine + N-methylnicotinate
Thus, the two substrates of this enzyme are S-adenosyl methionine and nicotinate, whereas its two products are S-adenosylhomocysteine and N-methylnicotinate.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:nicotinate N-methyltransferase. Other names in common use include furanocoumarin 8-methyltransferase, and furanocoumarin 8-O-methyltransferase. This enzyme participates in nicotinate and nicotinamide metabolism.
Contents |
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 5MHT.
References
- IUBMB entry for 2.1.1.7
- BRENDA references for 2.1.1.7 (Recommended.)
- PubMed references for 2.1.1.7
- PubMed Central references for 2.1.1.7
- Google Scholar references for 2.1.1.7
- Joshi JG and Handler P (1960). "Biosynthesis of trigonelline". J. Biol. Chem. 235: 2981–2983.
External links
-
- The CAS registry number for this enzyme class is 9029-79-2.
Gene Ontology (GO) codes
 |
This transferase article is a stub. You can help Wikipedia by expanding it. |
Wikipedia content modification information:
- This page was last modified on 11 October 2008, at 16:17.
Wikipedia Authorship and Review
Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.
Wikipedia Usage Guidelines
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "Nicotinate N-methyltransferase".
The URL for this specific entry is:
All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.