Nisoldipine

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Nisoldipine
Systematic (IUPAC) name
methyl2- methylpropyl2,6-dimethyl-4-(2-nitrophenyl)- 1,4-dihydropyridine-3,5-dicarboxylate
Identifiers
CAS number 63675-72-9
ATC code C08CA07
PubChem 4499
DrugBank APRD00635
Chemical data
Formula C20H24N2O6 
Mol. mass 388.414 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 99%
Metabolism  ?
Half life 7-12 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

C(US)
Legal status

℞-only(US)
Routes Oral

Nisoldipine (INN) is a calcium channel blocker of the dihydropyridine class. It sold in the United States under the proprietary name Sular.

External links

  • DDB 30009
  • Mielcarek J, Grobelny P, Szamburska O (2005). "The effect of beta-carotene on the photostability of nisoldipine.". Methods Find Exp Clin Pharmacol 27 (3): 167–71. doi:10.1358/mf.2005.27.3.890873. PMID 15834448. 
  • Missan S, Zhabyeyev P, Dyachok O, Jones S, McDonald T (2003). "Block of cardiac delayed-rectifier and inward-rectifier K+ currents by nisoldipine.". Br J Pharmacol 140 (5): 863–70. doi:10.1038/sj.bjp.0705518. PMID 14530219. 
  • Hamilton S, Houle L, Thadani U. "Rapid-release and coat-core formulations of nisoldipine in treatment of hypertension, angina, and heart failure.". Heart Dis 1 (5): 279–88. PMID 11720635. 
Tablets  This pharmacology-related article is a stub. You can help Wikipedia by expanding it.
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Calcium channel blockers (C08)
Dihydropyridines
Phenylalkylamines
Benzothiazepines

Wikipedia content modification information:

  • This page was last modified on 31 May 2008, at 14:26.

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