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Nitric oxide synthase 2A (inducible, hepatocytes)
PDB rendering based on 1nsi.
Available structures: 1nsi, 2nsi, 4nos
Identifiers
Symbols	NOS2A; NOS; HEP-NOS; INOS; NOS2
External IDs	OMIM: 163730 MGI: 97361 HomoloGene: 55473
Gene ontology Molecular function: • nitric-oxide synthase activity • iron ion binding • calcium ion binding • calmodulin binding • zinc ion binding • electron carrier activity • FMN binding • heme binding • protein homodimerization activity • FAD binding • NADP binding Cellular component: • cytoplasm • cytosol • cortical cytoskeleton • perinuclear region of cytoplasm Biological process: • response to hypoxia • electron transport • superoxide metabolic process • nitric oxide biosynthetic process • inflammatory response • defense response to bacterium
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	4843	18126
Ensembl	ENSG00000007171	n/a
Uniprot	P35228	n/a
Refseq	NM_000625 (mRNA) NP_000616 (protein)	XM_001001508 (mRNA) XP_001001508 (protein)
Location	Chr 17: 23.11 - 23.15 Mb	n/a
Pubmed search	[1]	[2]

Nitric oxide synthase 2A (inducible, hepatocytes), also known as NOS2A, is a human gene.

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in two transcript variants encoding different isoforms.^[1]

References

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Wikipedia content modification information:

• This page was last modified on 8 July 2008, at 06:28.

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