This MedLibrary.org supplementary page on Nucleotide sugars metabolism is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:
Related Sponsors
In nucleotide sugar metabolism a group of biochemicals known as nucleotide sugars act as donors for sugar residues in the glycosylation reactions that produce polysaccharides.1 They are substrates for glycosyltransferases.2 The nucleotide sugars are also intermediates in nucleotide sugar interconversions that produce some of the activated sugars needed for glycosylation reactions.1 Since most glycosylation takes place in the endoplasmic reticulum and golgi apparatus, there are a large family of nucleotide sugar transporters that allow nucleotide sugars to move from the cytoplasm, where they are produced, into the organelles where they are consumed.34
Nucleotide sugar metabolism is particularly well-studied in bacterial pathogens, such as E. coli and Mycobacterium tuberculosis, since these molecules are required for the synthesis of glycoconjugates on the surfaces of these organisms.56 These glycoconjugates are virulence factors and components of the bacterial cell wall. These pathways are also studied in plants, but here the enzymes involved are less well understood.7
References
- ^ a b Ginsburg V (1978). "Comparative biochemistry of nucleotide-linked sugars". Prog. Clin. Biol. Res. 23: 595–600. PMID 351635.
- ^ Rademacher T, Parekh R, Dwek R (1988). "Glycobiology". Annu Rev Biochem 57: 785–838. doi:. PMID 3052290.
- ^ Handford M, Rodriguez-Furlán C, Orellana A (2006). "Nucleotide-sugar transporters: structure, function and roles in vivo". Braz. J. Med. Biol. Res. 39 (9): 1149–58. PMID 16981043. http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000900002&lng=en&nrm=iso&tlng=en.
- ^ Gerardy-Schahn R, Oelmann S, Bakker H (2001). "Nucleotide sugar transporters: biological and functional aspects". Biochimie 83 (8): 775–82. doi:. PMID 11530210.
- ^ Samuel G, Reeves P (2003). "Biosynthesis of O-antigens: genes and pathways involved in nucleotide sugar precursor synthesis and O-antigen assembly". Carbohydr. Res. 338 (23): 2503–19. doi:. PMID 14670712.
- ^ Ma Y, Pan F, McNeil M (2002). "Formation of dTDP-rhamnose is essential for growth of mycobacteria". J. Bacteriol. 184 (12): 3392–5. doi:. PMID 12029057. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=12029057.
- ^ Seifert GJ (2004). "Nucleotide sugar interconversions and cell wall biosynthesis: how to bring the inside to the outside". Curr. Opin. Plant Biol. 7 (3): 277–84. doi:. PMID 15134748.
|
||||||||
 |
This biochemistry article is a stub. You can help Wikipedia by expanding it. |
Wikipedia content modification information:
- This page was last modified on 2 September 2008, at 16:00.
Wikipedia Authorship and Review
Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.
Wikipedia Usage Guidelines
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "Nucleotide sugars metabolism".
The URL for this specific entry is:
All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.