Orosomucoid

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Identifiers
Symbol ORM1
Entrez 5004
HUGO 8498
OMIM 138600
RefSeq NM_000607
UniProt P02763
Other data
Locus Chr. 9 q31-qter
orosomucoid 2
Identifiers
Symbol ORM2
Entrez 5005
HUGO 8499
OMIM 138610
RefSeq NM_000608
UniProt P19652
Other data
Locus Chr. 9 q31-qter

Alpha-1-acid glycoprotein is a simplified name for orosomucoid (ORM). ORM is an acute phase (Acute phase protein) plasma alpha-globulin glycoprotein and is modulated by two polymorphic genes. Is is synthesized primarily in hepatocytes and has a normal plasma concentration between 0.6-1.2 mg/mL (1-3% plasma protein).[1] Plasma levels are affected by pregnancy, certain drugs, and certain diseases, particularly HIV.[1]

The only established function of ORM is to act as a carrier of basic and neutrally charged lipophilic compounds. In medicine, it is known as the primary carrier of basic drugs (whereas albumin carries acidic drugs), steroids, and protease inhibitors.[1][2]

References

  1. ^ a b c Colombo S, Buclin T, Décosterd LA, Telenti A, Furrer H, Lee BL, Biollaz J, Eap CB (2006). "Orosomucoid (alpha1-acid glycoprotein) plasma concentration and genetic variants: effects on human immunodeficiency virus protease inhibitor clearance and cellular accumulation". Clin. Pharmacol. Ther. 80 (4): 307–18. doi:10.1016/j.clpt.2006.06.006. PMID 17015049. 
  2. ^ Urien S, Brée F, Testa B, Tillement JP (1991). "pH-dependency of basic ligand binding to alpha 1-acid glycoprotein (orosomucoid)". Biochem. J. 280 ( Pt 1): 277–80. PMID 1741754. 

External links

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Proteins: globulins
Serum
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v • d • e
Glycoproteins: mucoproteins
Mucin
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Acute phase proteins
Amyloid
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 This article on a gene on chromosome 9 is a stub. You can help Wikipedia by expanding it.

Wikipedia content modification information:

  • This page was last modified on 27 September 2008, at 20:58.

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