This MedLibrary.org supplementary page on Ototoxicity is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:
Related Sponsors
| Ototoxic hearing loss Classification and external resources |
|
| ICD-10 | H91.0 |
|---|---|
| DiseasesDB | 2874 |
| eMedicine | ent/699 |
Ototoxicity is damage of the ear (oto), specifically the cochlea or auditory nerve and sometimes the vestibulum, by a toxin (often medication).
Contents |
Causes
A number of drugs have been associated with damage to the cochlea. The best known are aminoglycoside antibiotics, aspirin, nicotine, some chemotherapy agents (cisplatin, carboplatin, vincristine) and some loop diuretics such as furosemide.
Erythromycin and some other macrolide antibiotics can induce temporary deafness, which resolves upon withdrawal of the drug.
Other chemicals such as toluene, mercury and carbon monoxide are also known ototoxic chemicals.
There appears to be a hereditary predisposition to ototoxic reactions.
Symptoms
Symptoms include partial or profound hearing loss, vertigo, and tinnitus.
Treatment
No specific treatment is available, but immediate withdrawal of the drug is warranted.
See also
External links
Wikipedia content modification information:
- This page was last modified on 23 July 2008, at 15:58.
Wikipedia Authorship and Review
Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.
Wikipedia Usage Guidelines
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "Ototoxicity".
The URL for this specific entry is:
All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.