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8-oxoguanine DNA glycosylase
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| PDB rendering based on 1ebm. | ||||||||||||||
| Available structures: 1ebm, 1fn7, 1hu0, 1ko9, 1lwv, 1lww, 1lwy, 1m3h, 1m3q, 1n39, 1n3a, 1n3c, 1yqk, 1yql, 1yqm, 1yqr, 2i5w, 2nob, 2noe, 2nof, 2noh, 2noi, 2nol, 2noz | ||||||||||||||
| Identifiers | ||||||||||||||
| Symbols | OGG1; HMMH; HOGG1; MUTM; OGH1 | |||||||||||||
| External IDs | OMIM: 601982 MGI: 1097693 HomoloGene: 1909 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 4968 | 18294 | ||||||||||||
| Ensembl | ENSG00000114026 | ENSMUSG00000030271 | ||||||||||||
| Uniprot | O15527 | Q3UIL3 | ||||||||||||
| Refseq | NM_002542 (mRNA) NP_002533 (protein) |
NM_010957 (mRNA) NP_035087 (protein) |
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| Location | Chr 3: 9.77 - 9.78 Mb | Chr 6: 113.29 - 113.3 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
8-oxoguanine glycosylase is a DNA glycosylase enzyme. It is involved in base excision repair.
It is the primary enzyme responsible for the excision of 7,8-dihydro-8-oxoguanine (8-oxoG), a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen species (ROS). The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. The N-terminus of this gene contains a mitochondrial targetting signal, essential for mitochondrial localization.[1]
References
Further reading
- Boiteux S, Radicella JP (2000). "The human OGG1 gene: structure, functions, and its implication in the process of carcinogenesis.". Arch. Biochem. Biophys. 377 (1): 1–8. doi:. PMID 10775435.
- Park J, Chen L, Tockman MS, et al. (2004). "The human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) DNA repair enzyme and its association with lung cancer risk.". Pharmacogenetics 14 (2): 103–9. PMID 15077011.
- Hung RJ, Hall J, Brennan P, Boffetta P (2006). "Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review.". Am. J. Epidemiol. 162 (10): 925–42. doi:. PMID 16221808.
External links
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Wikipedia content modification information:
- This page was last modified on 8 July 2008, at 04:29.
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