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Oxprenolol
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| Systematic (IUPAC) name | |
| 1-propan-2-ylamino-3-(2 -prop-2-enoxyphenoxy)-propan-2-ol |
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| Identifiers | |
| CAS number | |
| ATC code | C07 |
| PubChem | |
| Chemical data | |
| Formula | C15H23NO3 |
| Mol. mass | 265.348 |
| Pharmacokinetic data | |
| Bioavailability | 20-70% |
| Metabolism | Hepatic |
| Half life | 1-2hours |
| Excretion | Renal Lactic (In lactiferous females) |
| Therapeutic considerations | |
| Pregnancy cat. |
C(AU) |
| Legal status |
℞ Prescription only |
| Routes | oral |
Oxprenolol is a non-selective beta blocker with some intrinsic sympathomimetic activity. It is used for the treatment of angina pectoris and abnormal heart rhythms. It is also used for treating high blood pressure.
Oxprenolol is a lipophilic beta blocker which passes the blood-brain barrier more easily than water soluble beta blockers. As such, it is associated with a higher incidence of CNS-related side effects than hydrophilic ligands such as atenolol, sotalol and nadolol.[1]
Oxprenolol is a potent beta-blocker and should not be administered to asthmatics because it can cause irreversible airway failure and inflammation.citation needed
References
- ^ McDevitt DG (1987). "Comparison of pharmacokinetic properties of beta-adrenoceptor blocking drugs". Eur. Heart J. 8 Suppl M: 9–14. PMID 2897304.
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Wikipedia content modification information:
- This page was last modified on 22 June 2008, at 09:23.
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