P2RX7

This MedLibrary.org supplementary page on P2RX7 is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:

Related Sponsors

BM Pharmacy Generic pharmaceuticals at unbeatable prices. Insomnia, men's health, hair health, pain control. bmpharmacy.com
Online Pharmacy Carisoprodol, tadalafil, sildenafil, vardenafil and more... xlpharmacy.com
MedBasket.com Discreet. Inexpensive. Fast shipping. Great selection. What more can we say? medbasket.com
Frugalmed 2000 reasons to shop with us first. frugalmed.com
Ads by Tiva

Purinergic receptor P2X, ligand-gated ion channel, 7
Identifiers
Symbols P2RX7; MGC20089; P2X7
External IDs OMIM: 602566 MGI: 1339957 HomoloGene: 1925
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 5027 18439
Ensembl ENSG00000089041 ENSMUSG00000029468
Uniprot Q99572 Q3UN00
Refseq NM_002562 (mRNA)
NP_002553 (protein)		 NM_001038839 (mRNA)
NP_001033928 (protein)
Location Chr 12: 120.06 - 120.11 Mb Chr 5: 122.9 - 122.95 Mb
Pubmed search [1] [2]

Purinergic receptor P2X, ligand-gated ion channel, 7, also known as P2RX7, is a human gene.

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants which would encode different isoforms have been identified although some fit nonsense-mediated decay (NMD) criteria.[1]

Contents

See also

References

  1. ^ "Entrez Gene: P2RX7 purinergic receptor P2X, ligand-gated ion channel, 7".

Further reading

  • Gartland A, Buckley KA, Hipskind RA, Bowler WB, Gallagher JA. (2003). "P2 receptors in bone--modulation of osteoclast formation and activity via P2X7 activation.". Crit Rev Eukaryot Gene Expr. 13 (2-4): 237–42. PMID 14696970. 
  • Gartland A, Buckley KA, Bowler WB, Gallagher JA. (2003). "Blockade of the pore-forming P2X7 receptor inhibits formation of multinucleated human osteoclasts in vitro.". Calcif Tissue Int. 72 (4): 361–9. PMID 12874700. 
  • Bowler WB, Buckley KA, Gartland A, Hipskind RA, Bilbe G, Gallagher JA.. "Extracellular nucleotide signaling: a mechanism for integrating local and systemic responses in the activation of bone remodeling.". Bone 28 (5): 507–12. PMID 11344050. 
  • Gartland A, Hipskind RA, Gallagher JA, Bowler WB. (2001). "Expression of a P2X7 receptor by a subpopulation of human osteoblasts.". J Bone Miner Res . 16 (5): 846–56. PMID 11341329. 
  • Gartland A, Buckley KA, Hipskind RA, Perry MJ, Tobias JH, Buell G, Chessell I, Bowler WB, Gallagher JA. (2003). "Multinucleated osteoclast formation in vivo and in vitro by P2X7 receptor-deficient mice.". Crit Rev Eukaryot Gene Expr. 13 (2-4): 243–53. PMID 14696971. 
  • North RA (2002). "Molecular physiology of P2X receptors.". Physiol. Rev. 82 (4): 1013–67. doi:10.1152/physrev.00015.2002. PMID 12270951. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Rassendren F, Buell GN, Virginio C, et al. (1997). "The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA.". J. Biol. Chem. 272 (9): 5482–6. PMID 9038151. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Buell GN, Talabot F, Gos A, et al. (1999). "Gene structure and chromosomal localization of the human P2X7 receptor.". Recept. Channels 5 (6): 347–54. PMID 9826911. 
  • Gu BJ, Zhang W, Worthington RA, et al. (2001). "A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptor.". J. Biol. Chem. 276 (14): 11135–42. doi:10.1074/jbc.M010353200. PMID 11150303. 
  • Kim M, Jiang LH, Wilson HL, et al. (2002). "Proteomic and functional evidence for a P2X7 receptor signalling complex.". EMBO J. 20 (22): 6347–58. doi:10.1093/emboj/20.22.6347. PMID 11707406. 
  • Worthington RA, Smart ML, Gu BJ, et al. (2002). "Point mutations confer loss of ATP-induced human P2X(7) receptor function.". FEBS Lett. 512 (1-3): 43–6. PMID 11852049. 
  • Wiley JS, Dao-Ung LP, Gu BJ, et al. (2002). "A loss-of-function polymorphic mutation in the cytolytic P2X7 receptor gene and chronic lymphocytic leukaemia: a molecular study.". Lancet 359 (9312): 1114–9. PMID 11943260. 
  • Wilson HL, Wilson SA, Surprenant A, North RA (2002). "Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus.". J. Biol. Chem. 277 (37): 34017–23. doi:10.1074/jbc.M205120200. PMID 12107182. 
  • Atkinson L, Milligan CJ, Buckley NJ, Deuchars J (2002). "An ATP-gated ion channel at the cell nucleus.". Nature 420 (6911): 42. doi:10.1038/420042a. PMID 12422208. 
  • Budagian V, Bulanova E, Brovko L, et al. (2003). "Signaling through P2X7 receptor in human T cells involves p56lck, MAP kinases, and transcription factors AP-1 and NF-kappa B.". J. Biol. Chem. 278 (3): 1549–60. doi:10.1074/jbc.M206383200. PMID 12424250. 
  • Sluyter R, Wiley JS (2003). "Extracellular adenosine 5'-triphosphate induces a loss of CD23 from human dendritic cells via activation of P2X7 receptors.". Int. Immunol. 14 (12): 1415–21. PMID 12456589. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Wiley JS, Dao-Ung LP, Li C, et al. (2003). "An Ile-568 to Asn polymorphism prevents normal trafficking and function of the human P2X7 receptor.". J. Biol. Chem. 278 (19): 17108–13. doi:10.1074/jbc.M212759200. PMID 12586825. 
  • Barden JA, Sluyter R, Gu BJ, Wiley JS (2003). "Specific detection of non-functional human P2X(7) receptors in HEK293 cells and B-lymphocytes.". FEBS Lett. 538 (1-3): 159–62. PMID 12633871. 
  • Verhoef PA, Estacion M, Schilling W, Dubyak GR (2003). "P2X7 receptor-dependent blebbing and the activation of Rho-effector kinases, caspases, and IL-1 beta release.". J. Immunol. 170 (11): 5728–38. PMID 12759456. 
  • Greig AV, Linge C, Terenghi G, et al. (2003). "Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes.". J. Invest. Dermatol. 120 (6): 1007–15. PMID 12787128. 
  • Denlinger LC, Sommer JA, Parker K, et al. (2003). "Mutation of a dibasic amino acid motif within the C terminus of the P2X7 nucleotide receptor results in trafficking defects and impaired function.". J. Immunol. 171 (3): 1304–11. PMID 12874219. 

External links

 This membrane protein-related article is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
Ion channel, receptor: ligand-gated ion channels
Cys-loop receptors
5-HT3 (A, B, C, D, E)
GABA A (α1, α2, α3, α4, α5, α6, β1, β2, β3, γ1, γ2, γ3, δ, ε, π, θ) • GABA C (ρ1, ρ2, ρ3)
α1 • α2 • α3 • α4 • β
monomers: α1 • α2 • α3 • α4 • α5 • α6 • α7 • α9 • α10 • β1 • β2 • β3 • β4 • δ • ε
pentamers: (α4)2(β2)3 • (α7)5 • (α1)2(β4)3 - Ganglion type • (α1)2β1δε - Muscle type
Ionotropic glutamates
AMPA (1, 2, 3, 4) • Kainate (1, 2, 3, 4, 5)  • NMDA (1, 2A, 2B, 2C, 2D, 3A, 3B, L1A, L1B)
ATP-gated channels

Wikipedia content modification information:

  • This page was last modified on 8 July 2008, at 07:16.

Wikipedia Authorship and Review

Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.

Wikipedia Usage Guidelines

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "P2RX7".

The URL for this specific entry is:

All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.