PDK1

This MedLibrary.org supplementary page on PDK1 is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:

Related Sponsors

BM Pharmacy Generic pharmaceuticals at unbeatable prices. Insomnia, men's health, hair health, pain control. bmpharmacy.com
Online Pharmacy Carisoprodol, tadalafil, sildenafil, vardenafil and more... xlpharmacy.com
MedBasket.com Discreet. Inexpensive. Fast shipping. Great selection. What more can we say? medbasket.com
Frugalmed 2000 reasons to shop with us first. frugalmed.com
Ads by Tiva

Not to be confused with the master kinase PDK1, 3-phosphoinositide-dependent protein kinase (PDPK1).



Pyruvate dehydrogenase kinase, isozyme 1
Identifiers
Symbols PDK1;
External IDs OMIM: 602524 MGI: 1926119 HomoloGene: 20576
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 5163 228026
Ensembl ENSG00000152256 ENSMUSG00000006494
Uniprot Q15118 Q3U5E5
Refseq NM_002610 (mRNA)
NP_002601 (protein)		 NM_172665 (mRNA)
NP_766253 (protein)
Location Chr 2: 173.13 - 173.17 Mb Chr 2: 71.67 - 71.7 Mb
Pubmed search [1] [2]

Pyruvate dehydrogenase kinase, isozyme 1, also known as PDK1, is a human gene.[1] It codes for an isozyme of pyruvate dehydrogenase kinase (PDK).

Pyruvate dehydrogenase (PDH) is a part of a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation.[1]

References

  1. ^ a b "Entrez Gene: PDK1 pyruvate dehydrogenase kinase, isozyme 1".

Further reading

  • Sugden MC, Holness MJ (2003). "Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs". Am. J. Physiol. Endocrinol. Metab. 284 (5): E855–62. doi:10.1152/ajpendo.00526.2002 (inactive 2008-06-23). PMID 12676647. 
  • Gudi R, Bowker-Kinley MM, Kedishvili NY, et al. (1996). "Diversity of the pyruvate dehydrogenase kinase gene family in humans". J. Biol. Chem. 270 (48): 28989–94. PMID 7499431. 
  • Liu S, Baker JC, Andrews PC, Roche TE (1995). "Recombinant expression and evaluation of the lipoyl domains of the dihydrolipoyl acetyltransferase component of the human pyruvate dehydrogenase complex". Arch. Biochem. Biophys. 316 (2): 926–40. doi:10.1006/abbi.1995.1124. PMID 7864652. 
  • Kolobova E, Tuganova A, Boulatnikov I, Popov KM (2001). "Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites". Biochem. J. 358 (Pt 1): 69–77. doi:10.1042/0264-6021:3580069. PMID 11485553. 
  • Korotchkina LG, Patel MS (2001). "Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase". J. Biol. Chem. 276 (40): 37223–9. doi:10.1074/jbc.M103069200. PMID 11486000. 
  • Tuganova A, Boulatnikov I, Popov KM (2002). "Interaction between the individual isoenzymes of pyruvate dehydrogenase kinase and the inner lipoyl-bearing domain of transacetylase component of pyruvate dehydrogenase complex". Biochem. J. 366 (Pt 1): 129–36. doi:10.1042/BJ20020301. PMID 11978179. 
 This article on a gene on chromosome 2 is a stub. You can help Wikipedia by expanding it.

Wikipedia content modification information:

  • This page was last modified on 20 July 2008, at 09:25.

Wikipedia Authorship and Review

Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.

Wikipedia Usage Guidelines

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "PDK1".

The URL for this specific entry is:

All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.