Pancreatic polypeptide receptor 1

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Pancreatic polypeptide receptor 1
Identifiers
Symbols PPYR1; PP1; MGC116897; NPY4-R; NPY4R; Y4
External IDs OMIM: 601790 MGI: 105374 HomoloGene: 38119
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 5540 19065
Ensembl ENSG00000204174 ENSMUSG00000048337
Uniprot P50391 Q3UN46
Refseq XM_001129329 (mRNA)
XP_001129329 (protein)		 NM_008919 (mRNA)
NP_032945 (protein)
Location Chr 10: 46.5 - 46.51 Mb Chr 14: 32.97 - 32.98 Mb
Pubmed search [1] [2]

Pancreatic polypeptide receptor 1, also known as PPYR1, is a human gene.[1]


See also

References

  1. ^ "Entrez Gene: PPYR1 pancreatic polypeptide receptor 1".

Further reading

  • Keire DA, Bowers CW, Solomon TE, Reeve JR (2002). "Structure and receptor binding of PYY analogs.". Peptides 23 (2): 305–21. PMID 11825645. 
  • Balasubramaniam A (2002). "Clinical potentials of neuropeptide Y family of hormones.". Am. J. Surg. 183 (4): 430–4. PMID 11975932. 
  • Parker E, Van Heek M, Stamford A (2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status.". Eur. J. Pharmacol. 440 (2-3): 173–87. PMID 12007534. 
  • Benaim G, Villalobo A (2002). "Phosphorylation of calmodulin. Functional implications.". Eur. J. Biochem. 269 (15): 3619–31. PMID 12153558. 
  • Lundell I, Blomqvist AG, Berglund MM, et al. (1996). "Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.". J. Biol. Chem. 270 (49): 29123–8. PMID 7493937. 
  • Bard JA, Walker MW, Branchek TA, Weinshank RL (1995). "Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.". J. Biol. Chem. 270 (45): 26762–5. PMID 7592911. 
  • Yan H, Yang J, Marasco J, et al. (1996). "Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.". Proc. Natl. Acad. Sci. U.S.A. 93 (10): 4661–5. PMID 8643460. 
  • Kawabe T, Muslin AJ, Korsmeyer SJ (1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint.". Nature 385 (6615): 454–8. doi:10.1038/385454a0. PMID 9009195. 
  • Lutz CM, Richards JE, Scott KL, et al. (1998). "Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY.". Genomics 46 (2): 287–90. doi:10.1006/geno.1997.5024. PMID 9417917. 
  • Darby K, Eyre HJ, Lapsys N, et al. (1998). "Assignment of the Y4 receptor gene (PPYR1) to human chromosome 10q11.2 and mouse chromosome 14.". Genomics 46 (3): 513–5. doi:10.1006/geno.1997.5071. PMID 9441761. 
  • Hsieh-Wilson LC, Allen PB, Watanabe T, et al. (1999). "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1.". Biochemistry 38 (14): 4365–73. doi:10.1021/bi982900m. PMID 10194355. 
  • Smith FD, Oxford GS, Milgram SL (1999). "Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein.". J. Biol. Chem. 274 (28): 19894–900. PMID 10391935. 
  • Marx SO, Reiken S, Hisamatsu Y, et al. (2000). "PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.". Cell 101 (4): 365–76. PMID 10830164. 
  • Connor JH, Weiser DC, Li S, et al. (2001). "Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.". Mol. Cell. Biol. 21 (20): 6841–50. doi:10.1128/MCB.21.20.6841-6850.2001. PMID 11564868. 
  • Cavadas C, Silva AP, Mosimann F, et al. (2001). "NPY regulates catecholamine secretion from human adrenal chromaffin cells.". J. Clin. Endocrinol. Metab. 86 (12): 5956–63. PMID 11739470. 
  • Cox HM, Tough IR (2002). "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa.". Br. J. Pharmacol. 135 (6): 1505–12. doi:10.1038/sj.bjp.0704604. PMID 11906964. 
  • Wu DY, Tkachuck DC, Roberson RS, Schubach WH (2002). "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity.". J. Biol. Chem. 277 (31): 27706–15. doi:10.1074/jbc.M200955200. PMID 12016208. 
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v • d • e
Transmembrane receptor: G protein-coupled receptors
Class A: Rhodopsin like
α1 (A, B, D), α2 (A, B, C), β1, β2, β3
CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin (DP, EP (1, 2, 3, 4), PGF), Prostacyclin, Thromboxane
B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182)
Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(all but 5-HT3) 5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)
Other
Acetylcholine (M1, M2, M3, M4, M5) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)
Class B: Secretin like
Class C: Metabotropic
glutamate / pheromone
Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))
Frizzled / Smoothened
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened

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