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Pharmacogenomics is the branch of pharmacology which deals with the influence of genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with a drug's efficacy or toxicity. By doing so, pharmacogenomics aims to develop rational means to optimise drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Such approaches promise the advent of "personalized medicine"; in which drugs and drug combinations are optimized for each individual's unique genetic makeup.^[1]

Pharmacogenomics is the whole genome application of pharmacogenetics, which examines the single gene interactions with drugs.

See also

• Genomics
  • Chemogenomics
  • Structural genomics
  • Pharmacogenetics
  • Toxicogenomics
  • Clinomics
  • p450
• Pharmaceutical company
• Population groups in biomedicine

References

1. ^ "Guidance for Industry Pharmacogenomic Data Submissions" (PDF). U.S. Food and Drug Administration. March 2005. http://www.fda.gov/cder/guidance/6400fnl.pdf. Retrieved 2008-08-27. 

Pharmacogenomics is the study of a patient's genes to predict response to drugs and hence select the right drug and the right quantity.

FDA have Released a List of Genomic Biomarkers Predictive of Drug Interactions in August 1, 2008 http://www.fda.gov/cder/genomics/genomic_biomarkers_table.htm

External links

• Genomics @ FDA FDA's resource on genomics
• [1]Pharmacogenetics and Genomics magazine (previously Pharmacogenetics)
• [2]The Pharmacogenomics Journal, ISSN: 1470-269X
• [3]Pharmacogenomics Journal, (ISSN 1462-2416) Impact factor: 3.623
• Nature pharmacogenomics gateway
• PharmGKB The Pharmacogenetics and Pharmacogenomics Knowledge Base, an online free tool for Pharmacogenomics research
• NCBI Primer on Pharmacogenomics, a quick introduction to the promise of customised drugs.
• Pharmacogenomics: Drugs Designed for You, an accessible and comprehensive look at pharmacogenomics research, from the University of Utah's Genetic Science Learning Center
• A Drug to Call One's Own : Will medicine finally get personal? - Scientific American Magazine (August 2005)
• PGxNews.Org - Daily updates about advances in Pharmacogenomics and Personalized Medicine

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This page was last modified on 15 February 2010 at 07:20.

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http://en.wikipedia.org/w/index.php?title=Pharmacogenomics

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