Phenazone

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Phenazone
Systematic (IUPAC) name
1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one
Identifiers
CAS number 60-80-0
ATC code N02BB01
PubChem 2206
DrugBank DB01435
Chemical data
Formula C11H12N2O 
Mol. mass 188.226
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes  ?

Phenazone, or phenazon, is an analgesic. It was first synthesised by Ludwig Knorr in 1883. It is formed by reducing diortho-dinitrodiphenyl with sodium amalgam and methyl alcohol, or by heating diphenylene-ortho-dihydrazine with hydrochloric acid to 150 C. It crystallizes in needles which melt at 156 C. Potassium permanganate oxidizes it to pyridazine tetracarboxylic acid.

Contents

Synonyms

Analgesine, Antipyrine, Diméthyloxyquinazine, Oxydiméthylquinazine, Oxydiméthylquinizine, Pyrazoline

See also

Propyphenazone

Chimic Class

  • Pyrazole
  • Pyrazolinone

Pharmacology

Adverse effects

  • Allergy to pyrazolones
  • Nausea
  • Agranulocytosis
  • hepatotoxic
v • d • e
Anti-inflammatory and antirheumatic products (M01)
Anti-inflammatory and
antirheumatic products,
non-steroids
See also: NSAIDs
Pyrazolidine/Butylpyrazolidines: · Ampyrone · Clofezone · Kebuzone · Metamizole · Mofebutazone · Oxyphenbutazone · Phenazone · Phenylbutazone · Sulfinpyrazone ·

Acetic acid derivatives and related substances: · Aceclofenac · Acemetacin · Alclofenac · Bromfenac · Bumadizone · Bufexamac · Diclofenac · Difenpiramide · Etodolac · Fentiazac · Indometacin · Ketorolac · Lonazolac · Oxametacin · Proglumetacin · Sulindac · Tolmetin · Zomepirac ·

Oxicams: · Ampiroxicam · Droxicam · Lornoxicam · Meloxicam · Piroxicam · Tenoxicam ·

Propionic acid derivatives: · Alminoprofen · Benoxaprofen · Dexibuprofen · Dexketoprofen · Fenbufen · Fenoprofen · Flunoxaprofen · Flurbiprofen · Ibuprofen · Ibuproxam · Indoprofen · Ketoprofen · Naproxen · Oxaprozin · Pirprofen · Suprofen · Tiaprofenic acid ·

Fenamates: · Flufenamic acid · Meclofenamic acid · Mefenamic acid · Tolfenamic acid ·

Coxibs: · Celecoxib · Etoricoxib · Lumiracoxib · Parecoxib · Rofecoxib · Valdecoxib ·

other anti-inflammatory and antirheumatic agents, non-steroids: · Nabumetone · Niflumic acid · Azapropazone · Glucosamine · Benzydamine · Glycosaminoglycan · Magnesium salicylate · Proquazone · Superoxide dismutase/Orgotein · Nimesulide · Feprazone · Diacerein · Morniflumate · Tenidap · Oxaceprol · Chondroitin sulfate ·
Specific antirheumatic
agents
v • d • e
Non-steroidal anti-inflammatory drug (NSAID) products (primarily M01A and M02A, also N02BA)
Salicylates
Arylalkanoic acids
2-Arylpropionic acids
(profens)
N-Arylanthranilic acids
(fenamic acids)
Pyrazolidine derivatives
Oxicams
COX-2 inhibitors
Sulphonanilides
Topically used products
Others
Items listed in bold indicate initially developed compounds of specific groups. †Withdrawn drugs. ‡Veterinary use medications.
v • d • e
Analgesic products (N02A, N02B)
Opioids
See also: Opioids template
Opium & Alkaloids Thereof
Semi-Synthetic Opium
Derivatives
Synthetic Opioids
Pyrazolones
Cannabinoids
Anilides
Non-Steroidal
Anti-Inflammatories
See also: NSAIDs template
Propionic Acid NSAIDs
Oxicam NSAIDs
Acetic Acid NSAIDs
COX-2 NSAIDs
Anthranilic Acid
(Fenamate) NSAIDS
Salicylate NSAIDS

Aspirin (Acetylsalicylic Acid) · Benorylate · Diflunisal · Ethenzamide · Magnesium Salicylate · Salicin · Salicylamide · Salsalate · Trisalate
Other NSAIDS
Atypical, Adjunct
& Miscellaneous

Wikipedia content modification information:

  • This page was last modified on 21 August 2008, at 04:47.

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