Phenformin

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Phenformin
Systematic (IUPAC) name
2-(N-phenethylcarbamimidoyl)guanidine
Identifiers
CAS number 114-86-3
ATC code A10BA01
PubChem 8249
DrugBank APRD00511
Chemical data
Formula C10H15N5 
Mol. mass 205.26 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes  ?

Phenformin is an anti-diabetic drug from the biguanide class. It is no longer widely available because it is known to induce lactic acidosis.[1]

Like metformin, phenformin leads to weight loss, something often desirable in type 2 diabetics, and it is for this reason that there is still some interest in it.[2]

References

  1. ^ Enia G, Garozzo M, Zoccali C (1997). "Lactic acidosis induced by phenformin is still a public health problem in Italy.". BMJ 315 (7120): 1466–7. PMID 9418116. 
  2. ^ Rosand J, Friedberg J, Yang J (1997). "Fatal phenformin-associated lactic acidosis.". Ann Intern Med 127 (2): 170. PMID 9230023. 
v • d • e
Oral antidiabetic drugs and Insulin analogs (A10)
Insulin sensitizers
Metformin, Buformin‡, Phenformin‡
Secretagogues
Alpha-glucosidase inhibitors
Amylin analog
Experimental
SGLT2 inhibitor
Insulin analogs
†Undergoing clinical trials. ‡ Withdrawn from market. §Development halted.

Wikipedia content modification information:

  • This page was last modified on 9 October 2008, at 20:21.

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