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| Phospholamban pentamer | ||
| Identifiers | ||
|---|---|---|
| Symbol | Phospholamban | |
| Pfam | PF04272 | |
| InterPro | IPR005984 | |
| SCOP | 1fjk | |
| TCDB | 8.A.11 | |
| OPM family | 70 | |
| OPM protein | 1zll | |
| Available PDB structures:
1n7lA:1-52 1plnD:35-52 1k9nA:35-52 1plp :1-24 1zllE:1-52 1kchA:35-52 1pslC:35-52 1fjkA:1-52 1fjpA:1-52 |
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| Identifiers | |
| Symbol | PLN |
| Alt. Symbols | PLB |
| Entrez | 5350 |
| HUGO | 9080 |
| OMIM | 172405 |
| RefSeq | NM_002667 |
| UniProt | P26678 |
| Other data | |
| Locus | Chr. 6 q22.1 |
Phospholamban is a 52 amino acid integral membrane protein that regulates the Ca2+ pump in cardiac muscle and skeletal muscle cells.
When phospholabman is phosphorylated by PKA its ability to to inhibit the sarcoplasmic reticulum calcium pump (SERCA) is lost. [1]Thus, activators of PKA, such as the beta-adrenergic agonist epinephrine (reseased by sympathetic stiumlation) may enhance the rate of cardiac myocyte relaxation. Additionally, since SERCA is more active, the next action potential will cause an increased release of calcium resulting in increased contraction (positive inotropic effect). When phospholamban is not phosphorylated, such as when PKA is inactive, it can interact with and inhibit SERCA. The overall effect of phospholamban is to speed up the rate of muscle relaxation and increase contractility thereby increasing heart rate and stroke volume respectively.
Gene knockout of phospholamban results in animals with hyperdynamic hearts, with little apparent negative consequence.
References
- Karim, C. B., T. L. Kirby, Z. Zhang, Y. Nesmelov, and D. D. Thomas. 2004. Phospholamban structural dynamics in lipid bilayers probed by a spin label rigidly coupled to the peptide backbone. Proc Natl Acad Sci USA, 101(40): 14437-14442. Entrez PubMed 15448204
- Brittsan, A. G. & Kranias, E. G. Phospholamban and cardiac contractile function. J. Mol. Cell. Cardiol. 32, 2131-2139 (2000). Entrez PubMed 11112989
External links
- UMich Orientation of Proteins in Membranes families/superfamily-70 - Orientations of phospholamban and sarcolipin in membrane]
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Wikipedia content modification information:
- This page was last modified on 19 September 2008, at 19:10.
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