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Picrotoxin
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| Systematic (IUPAC) name | |
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| Identifiers | |
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| ATC code | ? |
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| Chemical data | |
| Formula | C30H34O13 |
| Mol. mass | 602.583 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
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Picrotoxin, also known as cocculin, is a poisonous crystalline plant alkaloid, first isolated by Boullay in 1812.
Found primarily in Cocculus indicus and Anamirta cocculus, it has a strong physiological action. It acts as a non-competitive antagonist of GABA A receptors. As GABA itself is an inhibitory neurotransmitter, infusion of picrotoxin has a stimulative effect.
Chemical structure
Picrotoxin (C30H34O13) consists of two substances, picrotoxinin (C15H1606) and picrotin (C15H1807).
References
- L. Dupont, O. Dideberg, J. Lamotte-Brasseur et L. Angenot (1976). "Structure cristalline et moléculaire de la picrotoxine, C15H16O6.C15H18O7". Acta Cryst. B32: 2987–2993. (in French)
External links
- Ehrenberger K, Benkoe E, Felix D (1982). "Suppressive action of picrotoxin, a GABA antagonist, on labyrinthine spontaneous nystagmus and vertigo in man". Acta Otolaryngol. 93 (3-4): 269–73. doi:. PMID 7064710.
- Basic Neurochemistry: GABA Receptor Physiology and Pharmacology
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Wikipedia content modification information:
- This page was last modified on 22 June 2008, at 15:23.
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