Plasminogen

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Plasminogen
PDB rendering based on 1b2i.
Available structures: 1b2i, 1bml, 1bui, 1cea, 1ceb, 1ddj, 1hpj, 1hpk, 1i5k, 1ki0, 1krn, 1l4d, 1l4z, 1pk4, 1pkr, 1pmk, 1qrz, 1rjx, 2doh, 2doi, 2pk4, 5hpg
Identifiers
Symbol(s) PLG; DKFZp779M0222
External IDs OMIM: 173350 MGI: 97620 HomoloGene: 55452
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 5340 18815
Ensembl ENSG00000122194 ENSMUSG00000059481
Uniprot P00747 Q3V1T9
Refseq NM_000301 (mRNA)
NP_000292 (protein)		 NM_008877 (mRNA)
NP_032903 (protein)
Location Chr 6: 161.04 - 161.09 Mb Chr 17: 12.22 - 12.26 Mb
Pubmed search [1] [2]

Plasmin is an important enzyme (EC 3.4.21.7) present in blood that degrades many blood plasma proteins, most notable, fibrin clots. The degradation of fibrin is termed fibrinolysis.

Contents

Functions

It is a serine protease that is released as plasminogen from the liver into the circulation and activated by tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), thrombin, fibrin, and factor XII (Hageman factor). It is inactivated by alpha 2-antiplasmin, a serine protease inhibitor (serpin).

Apart from fibrinolysis, plasmin proteolyses proteins in various other systems: It activates collagenases, some mediators of the complement system and weakens the wall of the Graafian follicle (leading to ovulation). It cleaves fibrin, fibronectin, thrombospondin, laminin, and von Willebrand factor.


Fibrinolysis (simplified). Blue arrows denote stimulation, and red arrows inhibition.

Pathology

Deficiency in plasmin may lead to thrombosis, as clots are not degraded adequately.

Further reading

  • Anglés-Cano E, Rojas G (2003). "Apolipoprotein(a): structure-function relationship at the lysine-binding site and plasminogen activator cleavage site". Biol. Chem. 383 (1): 93–9. PMID 11928826. 
  • Ranson M, Andronicos NM (2004). "Plasminogen binding and cancer: promises and pitfalls". Front. Biosci. 8: s294–304. PMID 12700073. 

External links

v • d • e
Proteins: coagulation
Coagulation factors
primary hemostasis: vWF

intrinsic pathway: HMWK/Bradykinin - Kallikrein - Hageman / FXII - FXI - FIX - FVIII

extrinsic pathway: Tissue factor / FIII - FVII

common pathway: FX - FV - (Pro)thrombin / FII, Fibrin / FI - FXIII
Inhibitors
Fibrinolysis
v • d • e
Endopeptidases: serine proteases/serine endopeptidases (EC 3.4.21)
Digestive enzymes
Coagulation
Complement system
Other immune system
Venombin
Other
v • d • e
Globulins: beta globulins

Wikipedia content modification information:

  • This page was last modified on 21 June 2008, at 23:02.

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