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| Plasmodium knowlesi |
Plasmodium knowlesi is a primate malaria parasite commonly found in Southeast Asia. It causes malaria in long-tailed macaques (Macaca fascicularis), but it may also infect humans, either naturally or artificially.
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Epidemiology
Reports of human P. knowlesi infections are confined to Southeast Asia,[1][2] particularly Malaysia,[3] but there are also reports on the Thai-Burmese border.[4] A fifth of the cases of malaria diagnosed in Sarawak, Malaysian Borneo are due to P. knowlesi.[3]
P. knowlesi infection is normally considered an infection of long-tailed (Macaca fascicularis) and pig-tailed (Macaca nemestrina) macaques, but humans who work at the forest fringe or enter the rainforest to work are at risk of being infected with P. knowlesi. The mosquito Anopheles latens is attracted to both macaques and humans and has been shown to be the main vector transmitting P. knowlesi to humans in the Kapit Division of Sarawak, Malaysian Borneo[5]. Within the monkey population in Peninsular Malaysia, A. hackeri, is believed to be the main vector of 'P. knowlesi' : although 'A. hackeri' is capable of transmitting malaria to humans,[6] it is not normally attracted to humans and therefore cannot be an important vector for transmission.[7]
Diagnosis
P. knowlesi infections is diagnosed by examining thick and thin blood films in the same way as other malarias. The appearance of P. knowlesi is similar to that of P. malariae and is unlikely to be correctly diagnosed except by using molecular detection assays [3]in a malaria reference laboratory.
Treatment
P. knowlesi infection responds well to treatment with chloroquine and primaquine.[3] A more recent study however found that P. knowlesi-infection can prove to be fatal just like P. falciparum-malaria, and hence those who reside in or have traveled to the South East Asia should be treated as intensively when found to be suffering from malaria.[8]
Plasmodium knowlesi genome data
References
- ^ Chin W, Contacos PG, Coatney RG, Kimbal HR. (1965). "A naturally acquired quotidian-type malaria in man transferable to monkeys". Science 149: 865. doi:. PMID 14332847.
- ^ Yap FL, Cadigan FC, Coatney GR. (1971). "A presumptive case of naturally occurring Plasmodium knowlesi malaria in man in Malaysia". Trans R Soc Trop Med Hyg 65 (6): 839–40. doi:. PMID 5003320.
- ^ a b c d Singh B, Lee KS, Matusop A, Radhakrishnan A, Shamsul SSG, Cox-Singh J, Thomas A, Conway DJ (2004). "A large focus of naturally acquired Plasmodium knowlesi infections in human beings". Lancet 363: 1017–24. doi:.
- ^ Jongwutiwes S, Putaporntip C, Iwasaki T, Sata T, Kanbara H. (2004). "Naturally acquired Plasmodium knowlesi malaria in human, Thailand". Emerg Infect Dis 10 (12): 2211–3. PMID 15663864.
- ^ Vythilingam I, Tan CH, Asmad M, Chan ST, Lee KS, Singh B. (2006). "Natural transmission of Plasmodium knowlesi to humans by Anopheles latens in Sarawak, Malaysia". Trans R Soc Trop Med Hyg 100: 1087–88. doi:.
- ^ Wharton RH, Eyles DE. (1961). "Anopheles hackeri, a vector of Plasmodium knowlesi in Malaya". Science 134: 279–80. doi:. PMID 13784726.
- ^ Reid JA, Weitz B. (1961). "Anopheline mosquitoes as vectors of animal malaria in Malaya". Ann Trop Med Parasitol 55: 180–6.
- ^ "Plasmodium knowlesi Malaria in Humans Is Widely Distributed and Potentially Life Threatening" (2008-01-15). Clinical Infectious Diseases 46: 165—171. University of Chicago Press/Infectious Diseases Society of America. doi:. PMID 18171245. Retrieved on 2008-07-17.
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