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Probucol
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| Systematic (IUPAC) name | |
| 2,6-ditert-butyl-4-[2-(3,5-ditert-butyl-4-hydroxyphenyl) sulfanylpropan-2-ylsulfanyl]phenol | |
| Identifiers | |
| CAS number | |
| ATC code | C10 |
| PubChem | |
| Chemical data | |
| Formula | C31H48O2S2 |
| Mol. mass | 516.844 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | ? |
Probucol is an anti-hyperlipidemic drug initially developed in the treatment of coronary artery disease. However, clinical trials were stopped after it was found that it causes long QT syndrome in patients. Probucol was initially developed in the 1970s by a chemical company to maximize airplane tire longevity.
Mechanism
Probucol lowers the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism. Additionally, probucol may inhibit cholesterol synthesis and delay cholesterol absorption [1]. Probucol is a powerful antioxidant which inhibits the oxidation of cholesterol in LDLs; this slows the formation of foam cells, which contribute to atherosclerotic plaques.
References
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Wikipedia content modification information:
- This page was last modified on 19 June 2008, at 13:12.
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