Proglumetacin

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Proglumetacin
Systematic (IUPAC) name
3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-
methylindol-3-yl]acetyl]oxyethyl]piperazin-1-yl]
propyl 4-(benzoylamino)-5-(dipropylamino)-
5-oxopentanoate
Identifiers
CAS number 57132-53-3 59209-40-4 (maleate)
ATC code M01AB14
PubChem 4921
Chemical data
Formula C46H58ClN5O8 
Mol. mass 844.43442 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic. Undergoes enterohepatic recirculation
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes  ?

Proglumetacin (usually as the maleate salt, trade names Afloxan, Protaxon and Proxil) is a non-steroidal anti-inflammatory drug. It is metabolized in the body to indometacin and proglumide,[1] a drug with antisecretory effects that helps prevent injury to the stomach lining.

References

  1. ^ Setnikar I, Arigoni R, Chisté R, Makovec F, Revel L (1987). "Plasma levels of proglumetacin and its metabolites after intravenous or oral administration in the dog". Arzneimittel-Forschung 37 (6): 698–702. PMID 3663267. 
Tablets  This pharmacology-related article is a stub. You can help Wikipedia by expanding it.
v • d • e
Anti-inflammatory and antirheumatic products (M01)
Anti-inflammatory and
antirheumatic products,
non-steroids
See also: NSAIDs
Acetic acid derivatives
and related substances
Propionic acid derivatives
Other
Specific antirheumatic
agents
Other
v • d • e
Non-steroidal anti-inflammatory drug (NSAID) products (primarily M01A and M02A, also N02BA)
Salicylates
Arylalkanoic acids
2-Arylpropionic acids
(profens)
N-Arylanthranilic acids
(fenamic acids)
Pyrazolidine derivatives
Oxicams
COX-2 inhibitors
Sulphonanilides
Topically used products
COX-inhibiting nitric oxide donators
Others
Items listed in bold indicate initially developed compounds of specific groups. †Withdrawn drugs. ‡Veterinary use medications.

Wikipedia content modification information:

  • This page was last modified on 27 April 2008, at 06:19.

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