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proprotein convertase subtilisin/kexin type 2
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| Identifiers | |
| Symbol | PCSK2 |
| Alt. Symbols | NEC2 |
| Entrez | 5126 |
| HUGO | 8744 |
| OMIM | 162151 |
| RefSeq | NM_002594 |
| UniProt | P16519 |
| Other data | |
| Locus | Chr. 20 p11.2 |
Proprotein convertase 2 (PC2) is a serine protease and proprotein convertase It is also referred to as "prohormone convertase 2". PC2, like proprotein convertase 1 (PC1), is an enzyme responsible for the maturation of many neuroendocrine peptides from their precursors, such as the conversion of proinsulin to insulin. PC2 plays only a minor role in insulin biosynthesis, but a greater role in glucagon biosynthesis compared to PC1. PC2 binds to the small acidic pan-neuroendocrine protein 7B2, and if this protein is not present, proPC2 cannot become an enzymatically active form.
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- This page was last modified on 12 May 2008, at 01:18.
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