Protein C inhibitor

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Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
PDB rendering based on 1lq8.
Available structures: 1lq8, 2hi9, 2ol2
Identifiers
Symbols SERPINA5; PAI3; PCI; PLANH3; PROCI
External IDs OMIM: 601841 MGI: 107817 HomoloGene: 20159
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 5104 268591
Ensembl ENSG00000188488 ENSMUSG00000041550
Uniprot P05154 Q5BKQ8
Refseq NM_000624 (mRNA)
NP_000615 (protein)		 NM_172953 (mRNA)
NP_766541 (protein)
Location Chr 14: 94.12 - 94.13 Mb Chr 12: 104.5 - 104.51 Mb
Pubmed search [1] [2]

Protein C inhibitor is a serpin which limits the expression of protein C.

See also

Further reading

  • Suzuki K, Hayashi T (2000). "cis-elements required for expression of human protein C inhibitor gene in HepG2 cells and its androgen-dependent expression in rat reproductive organs.". Semin. Thromb. Hemost. 26 (1): 75–83. PMID 10805286. 
  • Yasuda T, Nadano D, Iida R, et al. (1992). "Discovery of a genetic polymorphism of human plasma protein C inhibitor (PCI): genetic survey utilizing isoelectric focusing followed by immunoblotting, immunological and biochemical characterization.". Hum. Genet. 89 (3): 265–9. PMID 1318261. 
  • Laurell M, Christensson A, Abrahamsson PA, et al. (1992). "Protein C inhibitor in human body fluids. Seminal plasma is rich in inhibitor antigen deriving from cells throughout the male reproductive system.". J. Clin. Invest. 89 (4): 1094–101. PMID 1372913. 
  • Meijers JC, Chung DW (1991). "Organization of the gene coding for human protein C inhibitor (plasminogen activator inhibitor-3). Assignment of the gene to chromosome 14.". J. Biol. Chem. 266 (23): 15028–34. PMID 1714450. 
  • Kuhn LA, Griffin JH, Fisher CL, et al. (1990). "Elucidating the structural chemistry of glycosaminoglycan recognition by protein C inhibitor.". Proc. Natl. Acad. Sci. U.S.A. 87 (21): 8506–10. PMID 2172989. 
  • Meijers JC, Chung DW (1990). "Evidence for a glycine residue at position 316 in human protein C inhibitor.". Thromb. Res. 59 (2): 389–93. PMID 2173165. 
  • España F, Berrettini M, Griffin JH (1989). "Purification and characterization of plasma protein C inhibitor.". Thromb. Res. 55 (3): 369–84. PMID 2551064. 
  • Laurell M, Stenflo J (1990). "Protein C inhibitor from human plasma: characterization of native and cleaved inhibitor and demonstration of inhibitor complexes with plasma kallikrein.". Thromb. Haemost. 62 (3): 885–91. PMID 2556811. 
  • Geiger M, Huber K, Wojta J, et al. (1989). "Complex formation between urokinase and plasma protein C inhibitor in vitro and in vivo.". Blood 74 (2): 722–8. PMID 2752144. 
  • Suzuki K, Deyashiki Y, Nishioka J, et al. (1987). "Characterization of a cDNA for human protein C inhibitor. A new member of the plasma serine protease inhibitor superfamily.". J. Biol. Chem. 262 (2): 611–6. PMID 3027058. 
  • Suzuki K, Nishioka J, Hashimoto S (1983). "Protein C inhibitor. Purification from human plasma and characterization.". J. Biol. Chem. 258 (1): 163–8. PMID 6294098. 
  • Christensson A, Lilja H (1994). "Complex formation between protein C inhibitor and prostate-specific antigen in vitro and in human semen.". Eur. J. Biochem. 220 (1): 45–53. PMID 7509746. 
  • Zheng X, Geiger M, Ecke S, et al. (1994). "Inhibition of acrosin by protein C inhibitor and localization of protein C inhibitor to spermatozoa.". Am. J. Physiol. 267 (2 Pt 1): C466–72. PMID 7521127. 
  • Radtke KP, Fernández JA, Greengard JS, et al. (1994). "Protein C inhibitor is expressed in tubular cells of human kidney.". J. Clin. Invest. 94 (5): 2117–24. PMID 7525654. 
  • Hayashi S (1994). "Urinary protein C inhibitor binding region in the B beta-chain of human fibrinogen.". Blood Coagul. Fibrinolysis 4 (6): 921–6. PMID 8148485. 
  • Hayashi T, Suzuki K (1994). "Gene organization of human protein C inhibitor, a member of SERPIN family proteins encoded in five exons.". Int. J. Hematol. 58 (3): 213–24. PMID 8148499. 
  • Billingsley GD, Walter MA, Hammond GL, Cox DW (1993). "Physical mapping of four serpin genes: alpha 1-antitrypsin, alpha 1-antichymotrypsin, corticosteroid-binding globulin, and protein C inhibitor, within a 280-kb region on chromosome I4q32.1.". Am. J. Hum. Genet. 52 (2): 343–53. PMID 8381582. 
  • Hayashi S, Yamada K (1993). "Binding of urinary protein C inhibitor to fibrin(ogen) and its binding mechanism.". Blood Coagul. Fibrinolysis 4 (1): 153–8. PMID 8384496. 
  • Moore A, Penfold LM, Johnson JL, et al. (1993). "Human sperm-egg binding is inhibited by peptides corresponding to core region of an acrosomal serine protease inhibitor.". Mol. Reprod. Dev. 34 (3): 280–91. doi:10.1002/mrd.1080340308. PMID 8471250. 
  • Hayashi S, Wakizaka A (1996). "Urinary protein C inhibitor binding region in the A alpha-chain of human fibrinogen.". Blood Coagul. Fibrinolysis 6 (5): 382–7. PMID 8589203. 

External links

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Serpins
inhibitory
Cross class inhibitory
MENT · SCCA-1 · crmA
noninhibitory

Wikipedia content modification information:

  • This page was last modified on 8 July 2008, at 03:51.

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