Pyrilamine

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Mepyramine
Systematic (IUPAC) name
N1-(4-methoxybenzyl)- N2,N2-dimethyl- N1-(pyridin-2-yl)ethane- 1,2-diamine
Identifiers
CAS number 91-84-9
ATC code R06AC01 D04AA02
PubChem  ?
Chemical data
Formula C17H23N3O 
Mol. mass 285.38 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes  ?

Mepyramine (INN, also known as pyrilamine) [1] is a first generation antihistamine, targeting the H1 receptor. However, it rapidly permeates the brain and so often causes drowsiness as a side effect.

It is used in over-the-counter combination products for colds and menstrual symptoms.[2]

Side effects may include sedation/drowsiness, muscle weakness, and insomnia.[3]

References

  1. ^ Parsons, M. E. and Ganellin, C. R. (2006). "Histamine and its receptors". British Journal of Pharmacology 147: S127–S135. doi:10.1038/sj.bjp.0706440. PMID 16402096. 
  2. ^ Dysmenorrhea: How to Relieve Cramps
  3. ^ Pyrilamine Maleate patient advice including side effects

External links

v • d • e
Antipruritics (D04)
Antihistamines for topical use
Anesthetics for topical use
v • d • e
Histamine antagonists
H1 or
non-selective
Alkylamines
Ethanolamines
Aminoalkyl ethers)
Ethylenediamines
Phenothiazine Tricyclics
Other Tricyclics
Others (including
selective, 2nd gen,
3rd gen)
H2
H3
H4


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Wikipedia content modification information:

  • This page was last modified on 20 June 2008, at 10:33.

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