This MedLibrary.org supplementary page on RIMA is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:
Related Sponsors
RIMA redirects here. For the Régiments d'Infanterie de Marine of the French Army, see Troupes de marine
Reversible inhibitors of monoamine oxidase type-A (RIMAs) are a family of psychiatric drugs and natural compounds that inhibit monoamine oxidase temporarily and reversibly. They are mostly used for alleviating depression and dysthymia. Because their action is short-lived and selective, they have a better safety profile than the older MAOIs.
Moclobemide, brofaromine, and some beta-carbolines, such as harmaline, are examples of RIMAs.[1][2]
Functionality and safety
RIMAs, a subset of monoamine oxidase inhibitors (MAOIs), inhibit only isoenzyme A and are reversible. They are displaced from monoamine oxidase in the presence of tyramine,[1] rather than inhibiting its breakdown in the liver as general MAOIs do. Additionally, isoenzyme B remains free and continues to metabolize tyramine in the stomach, although this is less significant than the liver action. Thus, a special diet does not need to be so strictly adhered to, although eating excessively large amounts of tyramine-containing foods is not advisable.
While safer than general MAOIs, RIMAs still have highly dangerous and sometimes fatal interactions with many common drugs; in particular, they can cause serotonin syndrome when combined with almost any antidepressant or stimulant (prescribed or not), common migraine medications, certain herbs, or even most cold medicines (including decongestants, antihistamines, and cough syrup).citation needed
References
- ^ a b Lotufo-Neto F, Trivedi M, Thase ME (March 1999). "Meta-analysis of the reversible inhibitors of monoamine oxidase type A moclobemide and brofaromine for the treatment of depression". Neuropsychopharmacology 20 (3): 226–47. doi:. PMID 10063483.
- ^ Kim H, Sablin SO, Ramsay RR (January 1997). "Inhibition of monoamine oxidase A by beta-carboline derivatives". Arch. Biochem. Biophys. 337 (1): 137–42. doi:. PMID 8990278.
 |
This psychoactive drug-related article is a stub. You can help Wikipedia by expanding it. |
 |
This enzyme-related article is a stub. You can help Wikipedia by expanding it. |
Wikipedia content modification information:
- This page was last modified on 21 July 2008, at 08:51.
Wikipedia Authorship and Review
Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.
Wikipedia Usage Guidelines
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "RIMA".
The URL for this specific entry is:
All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.