This MedLibrary.org supplementary page on Raclopride is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:
Related Sponsors
 |
|
|
Raclopride
|
|
| Systematic (IUPAC) name | |
| 3,5-dichloro-N-[(1-ethylpyrrolidin-2-yl)methyl]- 2-hydroxy-6-methoxy-benzamide |
|
| Identifiers | |
| CAS number | |
| ATC code | ? |
| PubChem | |
| Chemical data | |
| Formula | C15H20Cl2N2O3 |
| Mol. mass | 347.236 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | 30 min |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Raclopride is a synthetic compound that acts as an antagonist on D2 dopamine receptors.[1] It can thus be used as a neuroleptic agent to treat schizophrenia. It can be radiolabelled with the carbon-11 radioisotope and used in positron emission tomography (PET) scanning to assess the degree of dopamine binding to the D2 neuroreceptor. For example, one study found decreasing binding with the personality trait detachment.[2]
References
- ^ C. Kohler, H. Hall, S. O. Ogren & L. Gawell (July 1985). "Specific in vitro and in vivo binding of 3H-raclopride. A potent substituted benzamide drug with high affinity for dopamine D-2 receptors in the rat brain". Biochemical Pharmacology 34 (13): 2251–2259. PMID 4015674.
- ^ Lars Farde, J. Petter Gustavsson & Erik Jönsson (February 1997). "D2 dopamine receptors and personality traits". Nature 385 (6617): 590. doi:. PMID 9024656.
 |
This pharmacology-related article is a stub. You can help Wikipedia by expanding it. |
|
|||||||||||||||||
Wikipedia content modification information:
- This page was last modified on 24 July 2008, at 04:32.
Wikipedia Authorship and Review
Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.
Wikipedia Usage Guidelines
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "Raclopride".
The URL for this specific entry is:
All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.