This MedLibrary.org supplementary page on Rapacuronium is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:
Related Sponsors
 |
This article or section relies largely or entirely upon a single source. Please help improve this article by introducing appropriate citations of additional sources. |
 |
|
|
Rapacuronium bromide
|
|
| Systematic (IUPAC) name | |
| [(2S,3S,5S,8R,9S,10S,13S,14S,16S,17S)- 3-acetyloxy-10,13-dimethyl-2-(1-piperidyl)-16- (1-prop-2-enyl-3,4,5,6-tetrahydro-2H-pyridin- 1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro- 1H-cyclopenta[a]phenanthren-17-yl]propanoate |
|
| Identifiers | |
| CAS number | |
| ATC code | ? |
| PubChem | |
| Chemical data | |
| Formula | C37H61N2O4+ |
| Mol. mass | 597.891 g/mol |
| Pharmacokinetic data | |
| Bioavailability | Not applicable |
| Protein binding | Variable |
| Metabolism | Hydrolyzed to active metabolites CYP system not involved |
| Half life | 141 minutes (mean) |
| Excretion | Renal and fecal |
| Therapeutic considerations | |
| Pregnancy cat. |
C(US) |
| Legal status |
Withdrawn (U.S) |
| Routes | Intravenous |
Rapacuronium bromide (trade name Raplon, Organon) is a rapidly acting, non-depolarizing neuromuscular blocker used in modern anaesthesia, to aid and enable endotracheal intubation, which is often necessary to assist in the controlled ventilation of unconscious patients during surgery and sometimes in intensive care. As a non-depolarizing agent, it does not cause initial stimulation of muscles before weakening them.
Due to risk of fatal bronchospasm, it was withdrawn from the United States market by the manufacturer on March 27, 2001.[1]
References
- ^ Shapse, Deborah (March 27, 2001). Voluntary Market WithdrawalPDF (10.8 KiB). Organon International. Retrieved on 2007-04-02.
 |
This pharmacology-related article is a stub. You can help Wikipedia by expanding it. |
Wikipedia content modification information:
- This page was last modified on 20 December 2007, at 13:20.
Wikipedia Authorship and Review
Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.
Wikipedia Usage Guidelines
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "Rapacuronium".
The URL for this specific entry is:
All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.