SCN8A

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Sodium channel, voltage gated, type VIII, alpha subunit
PDB rendering based on 1byy.
Available structures: 1byy
Identifiers
Symbols SCN8A; MED; CerIII; NaCh6; Nav1.6; PN4
External IDs OMIM: 600702 MGI: 103169 HomoloGene: 7927
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6334 20273
Ensembl ENSG00000196876 ENSMUSG00000023033
Uniprot Q9UQD0 Q9WTU3
Refseq NM_014191 (mRNA)
NP_055006 (protein)		 NM_011323 (mRNA)
NP_035453 (protein)
Location Chr 12: 50.36 - 50.49 Mb Chr 15: 100.78 - 100.87 Mb
Pubmed search [1] [2]

Sodium channel, voltage gated, type VIII, alpha subunit (SCN8A), also known as Nav1.6, is a human gene.[1]


See also

References

  1. ^ "Entrez Gene: SCN8A sodium channel, voltage gated, type VIII, alpha subunit".

Further reading

  • Catterall WA, Goldin AL, Waxman SG (2006). "International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.". Pharmacol. Rev. 57 (4): 397–409. doi:10.1124/pr.57.4.4. PMID 16382098. 
  • Burgess DL, Kohrman DC, Galt J, et al. (1995). "Mutation of a new sodium channel gene, Scn8a, in the mouse mutant 'motor endplate disease'.". Nat. Genet. 10 (4): 461–5. doi:10.1038/ng0895-461. PMID 7670495. 
  • Plummer NW, McBurney MW, Meisler MH (1997). "Alternative splicing of the sodium channel SCN8A predicts a truncated two-domain protein in fetal brain and non-neuronal cells.". J. Biol. Chem. 272 (38): 24008–15. PMID 9295353. 
  • Plummer NW, Galt J, Jones JM, et al. (1999). "Exon organization, coding sequence, physical mapping, and polymorphic intragenic markers for the human neuronal sodium channel gene SCN8A.". Genomics 54 (2): 287–96. doi:10.1006/geno.1998.5550. PMID 9828131. 
  • Anis Y, Nürnberg B, Visochek L, et al. (1999). "Activation of Go-proteins by membrane depolarization traced by in situ photoaffinity labeling of galphao-proteins with [alpha32P]GTP-azidoanilide.". J. Biol. Chem. 274 (11): 7431–40. PMID 10066808. 
  • Caldwell JH, Schaller KL, Lasher RS, et al. (2000). "Sodium channel Na(v)1.6 is localized at nodes of ranvier, dendrites, and synapses.". Proc. Natl. Acad. Sci. U.S.A. 97 (10): 5616–20. doi:10.1073/pnas.090034797. PMID 10779552. 
  • Wittmack EK, Rush AM, Craner MJ, et al. (2005). "Fibroblast growth factor homologous factor 2B: association with Nav1.6 and selective colocalization at nodes of Ranvier of dorsal root axons.". J. Neurosci. 24 (30): 6765–75. doi:10.1523/JNEUROSCI.1628-04.2004. PMID 15282281. 
  • Raymond CK, Castle J, Garrett-Engele P, et al. (2004). "Expression of alternatively spliced sodium channel alpha-subunit genes. Unique splicing patterns are observed in dorsal root ganglia.". J. Biol. Chem. 279 (44): 46234–41. doi:10.1074/jbc.M406387200. PMID 15302875. 
  • Drews VL, Lieberman AP, Meisler MH (2005). "Multiple transcripts of sodium channel SCN8A (Na(V)1.6) with alternative 5'- and 3'-untranslated regions and initial characterization of the SCN8A promoter.". Genomics 85 (2): 245–57. doi:10.1016/j.ygeno.2004.09.002. PMID 15676283. 
  • Wittmack EK, Rush AM, Hudmon A, et al. (2006). "Voltage-gated sodium channel Nav1.6 is modulated by p38 mitogen-activated protein kinase.". J. Neurosci. 25 (28): 6621–30. doi:10.1523/JNEUROSCI.0541-05.2005. PMID 16014723. 
  • Schiavon E, Sacco T, Cassulini RR, et al. (2006). "Resurgent current and voltage sensor trapping enhanced activation by a beta-scorpion toxin solely in Nav1.6 channel. Significance in mice Purkinje neurons.". J. Biol. Chem. 281 (29): 20326–37. doi:10.1074/jbc.M600565200. PMID 16702217. 
  • Shirahata E, Iwasaki H, Takagi M, et al. (2006). "Ankyrin-G regulates inactivation gating of the neuronal sodium channel, Nav1.6.". J. Neurophysiol. 96 (3): 1347–57. doi:10.1152/jn.01264.2005. PMID 16775201. 
  • Black JA, Newcombe J, Trapp BD, Waxman SG (2007). "Sodium channel expression within chronic multiple sclerosis plaques.". J. Neuropathol. Exp. Neurol. 66 (9): 828–37. doi:10.1097/nen.0b013e3181462841. PMID 17805013. 
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v • d • e
Membrane transport protein: ion channels
Ca2+: Calcium channel
L-type/Cavα (1.1, 1.2, 1.3, 1.4) • N-type/Cavα2.2 • P-type/Cavα(2.1) • Q-type/Cavα2.1 • R-type/Cavα2.3 • T-type/Cavα(3.2)
α2δ-subunits (1, 2) • β-subunits (β1, β2, β3, β4) • γ-subunits (γ1, γ2, γ3, γ4)
Other
Na+: Sodium channel
Navα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 7A) • Navβ (1, 2, 3, 4)
Other
K+: Potassium channel
Kvα (1-6) (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.10, 2.1, 2.2, 3.1, 3.2, 3.3, 3.4, 4.1, 4.2, 4.3, 5.1, 6.1, 6.2, 6.3, 6.4)
Kvα (7-12) (7.1, 7.2, 7.3, 7.4, 7.5, 8.1, 8.2, 9.1, 9.2, 9.3, 10.1, 10.2, 11.1/hERG, 11.2, 11.3, 12.1, 12.2, 12.3)
Kvβ (1, 2, 3) • KCNIP (1, 2, 3, 4) • minK/ISK • MiRP (1, 2, 3) • Shaker gene
Kir (1.1, 2.1, 2.2, 2.3, 2.4) • GIRK/Kir (3.1, 3.2, 3.3, 3.4) • Kir (4.1, 4.2, 5.1, 6.1, 6.2, 7.1)
K2P (1, 2, 3, 4, 5, 6, 7, 9, 10, 12, 13, 15, 16, 17, 18)
M+: TRP cation channel
TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (1, 2, 3) • TRPP (1, 2) • TRPV (1, 2, 3, 4, 5, 6)
Cl-: Chloride channel
CFTR • CLCA (1, 2, 3, 4) • CLCN (1, 2, 3, 4, 5, 6, 7, KA, KB) • CLIC (1, 2, 3, 4, 5, 6) • CLNS (1A, 1B)
Cyclic nucleotide-gated
α1, α2, α3, α4, β1, β3, H1, H2, H3, H4
Porin
Other/general

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