SCNN1B

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Sodium channel, nonvoltage-gated 1, beta (Liddle syndrome)
Identifiers
Symbols SCNN1B; ENaCb; ENaCbeta; SCNEB
External IDs OMIM: 600760 MGI: 104696 HomoloGene: 284
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6338 20277
Ensembl ENSG00000168447 ENSMUSG00000030873
Uniprot P51168 Q3TP51
Refseq NM_000336 (mRNA)
NP_000327 (protein)		 NM_011325 (mRNA)
NP_035455 (protein)
Location Chr 16: 23.22 - 23.3 Mb Chr 7: 121.66 - 121.71 Mb
Pubmed search [1] [2]

Sodium channel, nonvoltage-gated 1, beta (Liddle syndrome), also known as SCNN1B, is a human gene.[1]


Contents

See also

References

  1. ^ "Entrez Gene: SCNN1B sodium channel, nonvoltage-gated 1, beta (Liddle syndrome)".

Further reading

  • Alvarez de la Rosa D, Canessa CM, Fyfe GK, Zhang P (2000). "Structure and regulation of amiloride-sensitive sodium channels.". Annu. Rev. Physiol. 62: 573–94. doi:10.1146/annurev.physiol.62.1.573. PMID 10845103. 
  • Rossier BC, Pradervand S, Schild L, Hummler E (2002). "Epithelial sodium channel and the control of sodium balance: interaction between genetic and environmental factors.". Annu. Rev. Physiol. 64: 877–97. doi:10.1146/annurev.physiol.64.082101.143243. PMID 11826291. 
  • Peters KW, Qi J, Johnson JP, et al. (2002). "Role of snare proteins in CFTR and ENaC trafficking.". Pflugers Arch. 443 Suppl 1: S65–9. doi:10.1007/s004240100647. PMID 11845306. 
  • Edelheit O, Hanukoglu I, Gizewska M, et al. (2005). "Novel mutations in epithelial sodium channel (ENaC) subunit genes and phenotypic expression of multisystem pseudohypoaldosteronism.". Clin. Endocrinol. (Oxf) 62 (5): 547–53. doi:10.1111/j.1365-2265.2005.02255.x. PMID 15853823. 
  • Voilley N, Bassilana F, Mignon C, et al. (1996). "Cloning, chromosomal localization, and physical linkage of the beta and gamma subunits (SCNN1B and SCNN1G) of the human epithelial amiloride-sensitive sodium channel.". Genomics 28 (3): 560–5. doi:10.1006/geno.1995.1188. PMID 7490094. 
  • Waldmann R, Champigny G, Bassilana F, et al. (1996). "Molecular cloning and functional expression of a novel amiloride-sensitive Na+ channel.". J. Biol. Chem. 270 (46): 27411–4. PMID 7499195. 
  • Hansson JH, Nelson-Williams C, Suzuki H, et al. (1995). "Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome.". Nat. Genet. 11 (1): 76–82. doi:10.1038/ng0995-76. PMID 7550319. 
  • McDonald FJ, Price MP, Snyder PM, Welsh MJ (1995). "Cloning and expression of the beta- and gamma-subunits of the human epithelial sodium channel.". Am. J. Physiol. 268 (5 Pt 1): C1157–63. PMID 7762608. 
  • Shimkets RA, Warnock DG, Bositis CM, et al. (1994). "Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel.". Cell 79 (3): 407–14. PMID 7954808. 
  • Snyder PM, Price MP, McDonald FJ, et al. (1996). "Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial Na+ channel.". Cell 83 (6): 969–78. PMID 8521520. 
  • Hansson JH, Schild L, Lu Y, et al. (1996). "A de novo missense mutation of the beta subunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activity.". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11495–9. PMID 8524790. 
  • Chang SS, Grunder S, Hanukoglu A, et al. (1996). "Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1.". Nat. Genet. 12 (3): 248–53. doi:10.1038/ng0396-248. PMID 8589714. 
  • Tamura H, Schild L, Enomoto N, et al. (1996). "Liddle disease caused by a missense mutation of beta subunit of the epithelial sodium channel gene.". J. Clin. Invest. 97 (7): 1780–4. PMID 8601645. 
  • Firsov D, Schild L, Gautschi I, et al. (1997). "Cell surface expression of the epithelial Na channel and a mutant causing Liddle syndrome: a quantitative approach.". Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15370–5. PMID 8986818. 
  • Gründer S, Firsov D, Chang SS, et al. (1997). "A mutation causing pseudohypoaldosteronism type 1 identifies a conserved glycine that is involved in the gating of the epithelial sodium channel.". EMBO J. 16 (5): 899–907. doi:10.1093/emboj/16.5.899. PMID 9118951. 
  • Pirozzi G, McConnell SJ, Uveges AJ, et al. (1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets.". J. Biol. Chem. 272 (23): 14611–6. PMID 9169421. 
  • Inoue J, Iwaoka T, Tokunaga H, et al. (1998). "A family with Liddle's syndrome caused by a new missense mutation in the beta subunit of the epithelial sodium channel.". J. Clin. Endocrinol. Metab. 83 (6): 2210–3. PMID 9626162. 
  • Persu A, Barbry P, Bassilana F, et al. (1998). "Genetic analysis of the beta subunit of the epithelial Na+ channel in essential hypertension.". Hypertension 32 (1): 129–37. PMID 9674649. 
  • Uehara Y, Sasaguri M, Kinoshita A, et al. (1998). "Genetic analysis of the epithelial sodium channel in Liddle's syndrome.". J. Hypertens. 16 (8): 1131–5. PMID 9794716. 
  • Saxena A, Hanukoglu I, Strautnieks SS, et al. (1998). "Gene structure of the human amiloride-sensitive epithelial sodium channel beta subunit.". Biochem. Biophys. Res. Commun. 252 (1): 208–13. doi:10.1006/bbrc.1998.9625. PMID 9813171. 

External links

 This article on a gene on chromosome 16 is a stub. You can help Wikipedia by expanding it.
v • d • e
Membrane transport protein: ion channels
Ca2+: Calcium channel
L-type/Cavα (1.1, 1.2, 1.3, 1.4) • N-type/Cavα2.2 • P-type/Cavα(2.1) • Q-type/Cavα2.1 • R-type/Cavα2.3 • T-type/Cavα(3.2)
α2δ-subunits (1, 2) • β-subunits (β1, β2, β3, β4) • γ-subunits (γ1, γ2, γ3, γ4)
Cation channels of sperm • Two-pore channel (1, 2)
Ligand-gated
Na+: Sodium channel
Navα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 7A) • Navβ (1, 2, 3, 4)
Other
K+: Potassium channel
Kvα (1-6) (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.10, 2.1, 2.2, 3.1, 3.2, 3.3, 3.4, 4.1, 4.2, 4.3, 5.1, 6.1, 6.2, 6.3, 6.4)
Kvα (7-12) (7.1, 7.2, 7.3, 7.4, 7.5, 8.1, 8.2, 9.1, 9.2, 9.3, 10.1, 10.2, 11.1/hERG, 11.2, 11.3, 12.1, 12.2, 12.3)
Kvβ (1, 2, 3) • KCNIP (1, 2, 3, 4) • minK/ISK • MiRP (1, 2, 3) • Shaker gene
Kir (1.1, 2.1, 2.2, 2.3, 2.4) • GIRK/Kir (3.1, 3.2, 3.3, 3.4) • Kir (4.1, 4.2, 5.1, 6.1, 6.2, 7.1)
K2P (1, 2, 3, 4, 5, 6, 7, 9, 10, 12, 13, 15, 16, 17, 18)
M+: TRP cation channel
TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (1, 2, 3) • TRPP (1, 2) • TRPV (1, 2, 3, 4, 5, 6)
Cl-: Chloride channel
CFTR • CLCA (1, 2, 3, 4) • CLCN (1, 2, 3, 4, 5, 6, 7, KA, KB) • CLIC (1, 2, 3, 4, 5, 6, L1) • CLNS (1A, 1B)
Cyclic nucleotide-gated
α1, α2, α3, α4, β1, β3, H1, H2, H3, H4
Porin
Other/general

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  • This page was last modified on 13 July 2008, at 12:20.

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