SRC-1

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Nuclear receptor coactivator 1
PDB rendering based on 1oj5.
Available structures: 1oj5, 2c52, 2prg
Identifiers
Symbols NCOA1; SRC1; F-SRC-1; MGC129719; MGC129720; NCoA-1; RIP160
External IDs OMIM: 602691 MGI: 1276523 HomoloGene: 7859
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 8648 17977
Ensembl ENSG00000084676 ENSMUSG00000020647
Uniprot Q15788 Q3U3A3
Refseq NM_003743 (mRNA)
NP_003734 (protein)		 XM_001000135 (mRNA)
XP_001000135 (protein)
Location Chr 2: 24.66 - 24.85 Mb Chr 12: 4.26 - 4.49 Mb
Pubmed search [1] [2]


The nuclear receptor coactivator 1 (NCOA1) is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity (EC 2.3.1.48). NCOA1 is recruited to DNA promotion sites by ligand activated nuclear receptors. NCOA1 in turn acylates histones which makes downsteam DNA more accessible to transcription. Hence NCOA1 assists nuclear receptors in the upregulation of DNA expression.[1][2]

NCOA1 is also frequently called steroid receptor coactivator-1 (SRC-1).

External links

References

  1. ^ Onate SA, Tsai SY, Tsai MJ, O'Malley BW (1995). "Sequence and characterization of a coactivator for the steroid hormone receptor superfamily". Science 270 (5240): 1354–7. doi:10.1126/science.270.5240.1354. PMID 7481822. 
  2. ^ Onate SA, Boonyaratanakornkit V, Spencer TE, Tsai SY, Tsai MJ, Edwards DP, O'Malley BW (1998). "The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors". J Biol Chem 273 (20): 12101–8. doi:10.1074/jbc.273.20.12101. PMID 9575154. 

Further reading

  • Qi C, Zhu Y, Reddy JK (2001). "Peroxisome proliferator-activated receptors, coactivators, and downstream targets.". Cell Biochem. Biophys. 32 Spring: 187–204. PMID 11330046. 
 This biochemistry article is a stub. You can help Wikipedia by expanding it.
v • d • e
Transcription coregulators
Coactivators
ARA (54, 55, 70) • CARM1 • CRTC (1, 2, 3) • CBP • PNRC (1, 2) • PPARGC (1A, 1B) • TGFB1I1
NCOA1 (SRC-1) • NCOA2 (GRIP1/SRC-2/TIF2) • NCOA3 (AIB/SRC-3/TRAM-1) • NCOA4 (ARA70) • NCOA5 (CIA) • NCOA6 (RAP250) • NCOA7 (ERAP140)
Corepressors
Hairless homolog • NRIP1 (RIP140) • PELP-1 • RCOR1 • Rb • SIN3A • SIN3B • Tripartite motif family TRIM (24, 28, 33)
NCOR1 • NCOR2 (SMRT)
ATP-dependent remodeling factors

Wikipedia content modification information:

  • This page was last modified on 27 August 2008, at 17:55.

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