Scrub typhus

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Scrub typhus
Classification and external resources
Orientia tsutsugamushi
ICD-10 A75.3
ICD-9 081.2
DiseasesDB 31715
eMedicine derm/841  ped/2710
MeSH D012612

Scrub typhus is a form of typhus caused by Orientia tsutsugamushi.[1]

Although it is similar in presentation to other forms of typhus, it is caused by an agent in a different Genus, and is frequently classified separately from the other typhi.

Contents

Causes

It is transmitted by chiggers, which are found in areas of heavy scrub vegetation.

It is most common in Asia.[2] This variety of typhus was known in Japan as tsutsugamushi disease, hence the formal name, and was also prevalent in Malaysia and Australia.

Contact with species related to the chigger mite, found in many parts of the world, can also cause an intense irritation of the human skin.

It affects females more than males in Korea, but not in Japan.[3]

Symptoms

Symptoms include fever, headache, muscle pain, cough, and gastrointestinal symptoms. More virulent strains of O. tsutsugamushi can cause hemorrhaging and intravascular coagulation.

Vaccine

An early attempt to create a scrub typhus vaccine occurred in the United Kingdom in 1937 (with the Wellcome Foundation infecting around 300,000 cotton rats in a classified project called "Operation Tyburn", but the vaccine was not used.[4]

History

According to J. R. Audy, severe epidemics of the disease occurred among troops in what was then known as Burma and Ceylon during World War II.[5]

References

  1. ^ Tseng BY, Yang HH, Liou JH, Chen LK, Hsu YH (February 2008). "Immunohistochemical study of scrub typhus: a report of two cases". Kaohsiung J. Med. Sci. 24 (2): 92–8. PMID 18281226. 
  2. ^ scrub typhus at Dorland's Medical Dictionary
  3. ^ Bang HA, Lee MJ, Lee WC (March 2008). "Comparative research on epidemiological aspects of tsutsugamushi disease (scrub typhus) between Korea and Japan". Jpn. J. Infect. Dis. 61 (2): 148–50. PMID 18362409. 
  4. ^ "AWIC Newsletter: The Cotton Rat In Biomedical Reserach".
  5. ^ Audy, Jack Ralph (1968). Red mites and typhus. [London]: University of London, Athlone Press. ISBN 0-485-26318-1. 


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  • This page was last modified on 3 September 2008, at 01:29.

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