Welcome to the MedLibrary.org Wikipedia Supplement on Seventeenth chromosome -- Please Click to Return to Front Page

Chromosome 17 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 17 spans more than 81 million base pairs (the building material of DNA) and represents between 2.5 and 3 % of the total DNA in cells.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 17 likely contains between 1,200 and 1,500 genes. It also contains the Homeobox B gene cluster.

Genes

The following are some of the genes located on chromosome 17:

• ACADVL: acyl-coenzyme A dehydrogenase, very long chain
• ACTG1: actin, gamma 1
• ASPA: aspartoacylase (Canavan disease)
• BRCA1: breast cancer 1, early onset
• CBX1: chromobox homolog 1
• COL1A1: collagen, type I, alpha 1
• ERBB2: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
• FLCN: folliculin
• GALK1: galactokinase 1
• GFAP: glial fibrillary acidic protein
• KCNJ2: potassium inwardly-rectifying channel, subfamily J, member 2
• MYO15A: myosin XVA
• NF1: neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease)
• PMP22: peripheral myelin protein 22
• SHBG: Sex hormone binding globulin
• SLC6A4: Serotonin transporter
• TP53: tumor suppressor protein p53 (Li-Fraumeni syndrome), tumor suppressor gene
• USH1G: Usher syndrome 1G (autosomal recessive)
• RAI1: retinoic acid induced 1
• RARalpha: Retinoic acid receptor Alpha (involved in t(15,17) with PML)
• GRB7: Growth factor Receptor-Bound protein 7
• Several CC chemokines: CCL1, CCL2, CCL3, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL14, CCL15, CCL16, CCL18, and CCL23.

Diseases & disorders

The following diseases are related to genes on chromosome 17:

• Alexander disease
• Andersen-Tawil syndrome
• Birt-Hogg-Dubé syndrome
• Bladder cancer
• Breast cancer
• Camptomelic dysplasia
• Canavan disease
• Charcot-Marie-Tooth disease
• Charcot-Marie-Tooth disease, type 1
• Cystinosis
• Ehlers-Danlos syndrome
• Ehlers-Danlos syndrome, arthrochalasia type
• Ehlers-Danlos syndrome, classical type
• Galactosemia
• Hereditary neuropathy with liability to pressure palsies
• Li-Fraumeni syndrome
• Maturity onset diabetes of the young type 5
• Miller-Dieker syndrome
• Neurofibromatosis type I
• Nonsyndromic deafness
• Nonsyndromic deafness, autosomal dominant
• Nonsyndromic deafness, autosomal recessive
• Osteogenesis imperfecta
• Osteogenesis Imperfecta, Type I
• Osteogenesis Imperfecta, Type II
• Osteogenesis Imperfecta, Type III
• Osteogenesis Imperfecta, Type IV
• Smith-Magenis syndrome
• Usher syndrome
• Usher syndrome type I
• Very long-chain acyl-coenzyme A dehydrogenase deficiency

References

• Gilbert F (1998). "Disease genes and chromosomes: disease maps of the human genome. Chromosome 17". Genet Test 2 (4): 357–81. PMID 10464617. 

This genetics article is a stub. You can help Wikipedia by expanding it.

Wikipedia content modification information:

• This page was last modified on 11 August 2008, at 14:03.

Wikipedia Authorship and Review

Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.

Wikipedia Usage Guidelines

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "Seventeenth chromosome".

The URL for this specific entry is:

• http://medlibrary.org/medwiki/Seventeenth_chromosome

All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.