Sotalol

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Sotalol
Systematic (IUPAC) name
N-[4-(1-hydroxy-2-isopropylamino-
ethyl)-phenyl]-methanesulfonamide
Identifiers
CAS number 3930-20-9
ATC code C07AA07
PubChem 5253
Chemical data
Formula C12H20N2O3S 
Mol. mass 272.3624 g/mol
Pharmacokinetic data
Bioavailability >95%
Metabolism Not metabolised
Half life 12 hours
Excretion Renal
Lactic (In lactating females)
Therapeutic considerations
Pregnancy cat.

B(US)
Legal status

℞ Prescription only
Routes oral

Sotalol (trade names Betapace and Betapace AF, Berlex Laboratories, Sotalex and Sotacor, Bristol-Myers Squibb) is a drug used in individuals with rhythm disturbances (cardiac arrhythmias) of the heart, and to treat hypertension in some individuals.

Contents

Pharmacology

It falls into the class III antiarrhythmic agents because it inhibits the potassium ion channels in the heart. It is also a beta blocker because of its primary action on the β-adrenergic receptors in the heart.

By blocking the potassium channels, sotalol prolongs repolarization, therefore lengthening the QT interval and decreasing automaticity.

It also slows atrioventricular (AV) nodal conduction (beta-blocking effect).

Sotalol is a racemic mix of D and L enantiomers. The L isomer is a beta blocker.

Sotalol is not selected for its beta-blocking ability, but rather for its Class III (potassium blocking) properties.

Indications

Sotalol is used to treat ventricular tachycardias as well as atrial fibrillation. Betapace AF is specifically labeled for atrial fibrillation.

Some evidence suggests that sotalol should be avoided in the setting of decreased ejection fraction due to heart attack.[1]

Footnotes

  1. ^ Waldo A, Camm A, deRuyter H, Friedman P, MacNeil D, Pauls J, Pitt B, Pratt C, Schwartz P, Veltri E (1996). "Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. The SWORD Investigators. Survival With Oral d-Sotalol". Lancet 348 (9019): 7–12. doi:10.1016/S0140-6736(96)02149-6. PMID 8691967. 

See also

v • d • e
Beta blockers (C07)
Non-selective β antagonists
β1 antagonists (cardioselective)
Mixed α1/β antagonists
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Wikipedia content modification information:

  • This page was last modified on 22 June 2008, at 07:43.

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