Spirapril

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Spirapril
Systematic (IUPAC) name
(8S)-7-[(2S)-2-[[(1S)-1-ethoxycarbonyl-3-phenyl-propyl]
amino]propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-
carboxylic acid
Identifiers
CAS number 83647-97-6
ATC code C09AA11
PubChem 5311447
Chemical data
Formula C22H30N2O5S2 
Mol. mass 466.616 g/mol
Pharmacokinetic data
Bioavailability 50%
Metabolism converted to spiraprilat
Half life 30 to 35 hours
Excretion Hepatic and renal
Therapeutic considerations
Pregnancy cat.

D
Legal status

℞ Prescription only
Routes Oral

Spirapril hydrochloride (Renormax) is an ACE inhibitor antihypertensive drug used to treat hypertension.

Like many ACE inhibitors, this is a prodrug which is converted to the active metabolite spiraprilat following oral administration. Unlike other members of the group, it is eliminated both by renal and hepatic routes which may allow for greater use in patients with renal impairment.[1] However data on its effect upon the renal function is conflicting.[2]

Footnotes

  1. ^ Shohat J, Wittenberg C, Erman A, Rosenfeld J, Boner G (1999). "Acute and chronic effects of spirapril, alone or in combination with isradipine on kidney function and blood pressure in patients with reduced kidney function and hypertension.". Scand J Urol Nephrol 33 (1): 57–62. doi:10.1080/003655999750016294. PMID 10100366. 
  2. ^ Noble S, Sorkin E (1995). "Spirapril. A preliminary review of its pharmacology and therapeutic efficacy in the treatment of hypertension.". Drugs 49 (5): 750–66. PMID 7601014. 
v • d • e
Agents acting on the renin-angiotensin system (C09)
ACE inhibitors
Angiotensin II receptor antagonists (AIIRA)
Renin inhibitors
Structure of captopril, the first clinically successful ACE inhibitor  This antihypertensive-related article is a stub. You can help Wikipedia by expanding it.

Wikipedia content modification information:

  • This page was last modified on 10 September 2008, at 00:46.

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