This MedLibrary.org supplementary page on Subiculum is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:
Related Sponsors
| Brain: Subiculum | ||
|---|---|---|
.jpg) |
||
| Subiculum labeled at center left. | ||
 |
||
| Subiculum to CA1 transition Artist Don Cooper and Leah Leverich | ||
| Part of | Temporal lobe | |
| Artery | Posterior cerebral Anterior choroidal |
|
| Acronym(s) | S | |
| NeuroNames | hier-170 | |
| MeSH | Subiculum | |
The subiculum (Latin for "support") is the most inferior component of the hippocampal formation. It lies between the entorhinal cortex and the CA1 subfield of the hippocampus proper.
It receives input from CA1 and entorhinal cortical layer III pyramidal neurons and is the main output of the hippocampus. The pyramidal neurons send projections to the nucleus accumbens, septal nuclei, prefrontal cortex, hypothalamus, entorhinal cortex and amygdala.
The pyramidal neurons in the subiculum exhibit transitions between two modes of action potential output: bursting and single spiking. The transitions between these two modes is thought to be important for routing information out of the hippocampus.
It is the site responsible for ictal activity in some cases of human epilepsy. It has also been implicated in working memory and drug addiction.
References
- O'Mara, S.M., Commins, S., Anderson, M. & Gigg, J.(2001). The Subiculum: A review of form physiology and function. Prog Neurobiol, 64, 129-154.
- O’Mara, S.M. (2006). The Mammalian Subiculum: Contrasting and Complementary In Vivo and In Vitro Approaches to Subicular Function. Special Issue of Behavioural Brain Research, 174 (2), 197-312.
- "Switching Signals in the Brain," PLoS Biology, 3(6):e210, 2005 June.
- Donald C. Cooper, Sungkwon Chung, Nelson Spruston, "Output-Mode Transitions Are Controlled by Prolonged Inactivation of Sodium Channels in Pyramidal Neurons of Subiculum," PLoS Biology, 3(6):e175, 2005 June.
- Donald C. Cooper, Shannon J. Moore, Nathan P. Staff, and Nelson Spruston, "Psychostimulant-induced plasticity of intrinsic excitability in the ventral subiculum," Journal of Neuroscience, October 29, 2003, 23(30):9937-9946
External links
 |
This neuroanatomy article is a stub. You can help Wikipedia by expanding it. |
|
|||||||||||
|
||||||||
Wikipedia content modification information:
- This page was last modified on 2 August 2008, at 15:27.
Wikipedia Authorship and Review
Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.
Wikipedia Usage Guidelines
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "Subiculum".
The URL for this specific entry is:
All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.