TAP2

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Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Identifiers
Symbols TAP2; ABC18; ABCB3; APT2; D6S217E; PSF2; RING11
External IDs OMIM: 170261 MGI: 98484 HomoloGene: 37323
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6891 21355
Ensembl ENSG00000204267 ENSMUSG00000024339
Uniprot Q03519 Q3TXM1
Refseq NM_000544 (mRNA)
NP_000535 (protein)		 NM_011530 (mRNA)
NP_035660 (protein)
Location Chr 6: 32.9 - 32.91 Mb Chr 17: 33.81 - 33.83 Mb
Pubmed search [1] [2]

Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP), also known as TAP2, is a human gene.

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.[1]

Contents

See also

References

  1. ^ "Entrez Gene: TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)".

Further reading

  • Townsend A, Trowsdale J (1993). "The transporters associated with antigen presentation.". Semin. Cell Biol. 4 (1): 53–61. PMID 8453065. 
  • Beck S, Kelly A, Radley E, et al. (1992). "DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing.". J. Mol. Biol. 228 (2): 433–41. PMID 1453454. 
  • Bodmer JG, Marsh SG, Albert ED, et al. (1992). "Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system.". Tissue Antigens 39 (4): 161–73. PMID 1529427. 
  • Kelly A, Powis SH, Kerr LA, et al. (1992). "Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex.". Nature 355 (6361): 641–4. doi:10.1038/355641a0. PMID 1538751. 
  • Colonna M, Bresnahan M, Bahram S, et al. (1992). "Allelic variants of the human putative peptide transporter involved in antigen processing.". Proc. Natl. Acad. Sci. U.S.A. 89 (9): 3932–6. PMID 1570316. 
  • Powis SH, Mockridge I, Kelly A, et al. (1992). "Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex.". Proc. Natl. Acad. Sci. U.S.A. 89 (4): 1463–7. PMID 1741401. 
  • Bahram S, Arnold D, Bresnahan M, et al. (1991). "Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region.". Proc. Natl. Acad. Sci. U.S.A. 88 (22): 10094–8. PMID 1946428. 
  • Trowsdale J, Hanson I, Mockridge I, et al. (1991). "Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters.". Nature 348 (6303): 741–4. doi:10.1038/348741a0. PMID 2259383. 
  • de la Salle H, Hanau D, Fricker D, et al. (1994). "Homozygous human TAP peptide transporter mutation in HLA class I deficiency.". Science 265 (5169): 237–41. PMID 7517574. 
  • Cano P, Baxter-Lowe LA (1995). "Novel human TAP2*103 allele shows further polymorphism in the ATP-binding domain.". Tissue Antigens 45 (2): 139–42. PMID 7792761. 
  • Roby KF, Fei K, Yang Y, Hunt JS (1995). "Expression of HLA class II-associated peptide transporter and proteasome genes in human placentas and trophoblast cell lines.". Immunology 83 (3): 444–8. PMID 7835969. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Singal DP, Ye M, Qiu X, D'Souza M (1994). "Polymorphisms in the TAP2 gene and their association with rheumatoid arthritis.". Clin. Exp. Rheumatol. 12 (1): 29–33. PMID 8162639. 
  • Powis SH, Tonks S, Mockridge I, et al. (1993). "Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2.". Immunogenetics 37 (5): 373–80. PMID 8428770. 
  • Glynne R, Kerr LA, Mockridge I, et al. (1993). "The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing.". Eur. J. Immunol. 23 (4): 860–6. PMID 8458375. 
  • Beck S, Abdulla S, Alderton RP, et al. (1996). "Evolutionary dynamics of non-coding sequences within the class II region of the human MHC.". J. Mol. Biol. 255 (1): 1–13. doi:10.1006/jmbi.1996.0001. PMID 8568858. 
  • Ahn K, Meyer TH, Uebel S, et al. (1996). "Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47.". EMBO J. 15 (13): 3247–55. PMID 8670825. 
  • Pattanakitsakul S, Takeuchi F, Nabeta H, et al. (1996). "A novel TAP 2 gene RFLP observed in a Japanese.". Tissue Antigens 47 (4): 353–5. PMID 8773329. 
  • Lewis JW, Neisig A, Neefjes J, Elliott T (1997). "Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP.". Curr. Biol. 6 (7): 873–83. PMID 8805302. 

External links

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Membrane proteins, carrier proteins: membrane transport proteins
ABC-transporter
A1, A2, A3, A4, A7, A8, A12

B1, B2-3, B2, B3, B4, B5, B6, B7, B9, B11

C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11

D1, D2, D3, D4, E1, F1, F2

G1, G2, G4, Sterolin (G5, G8)
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