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Contents 1 Needs 2 Psychological effects 3 Alcohol 4 Unreferenced 5 Over-prescription? 6 Copyvio 7 Atypical and/or adjuvant analgesics 8 NSAIDs

Needs

Needs one or more references for the content, added tag.--FloNight 21:26, 25 November 2005 (UTC)

• Returning tag to top of talk page. Category:Articles lacking sources states that talk page is an appropriate place for the tag. This is the place tags are placed on medical articles that are undergoing work by various projects related to medicine]]--FloNight 18:26, 30 November 2005 (UTC)

Psychological effects

Can anyone add information about the psychological effects of stimulation-induced analgesia, stress-induced analgesia, and belief-induced analgesia? These are natural effects that, I assume, are simulated by analgesic drugs. My psych prof is saying something about it, and I just missed it. Experts, can you help with this? - 137.122.55.72 17:35, 7 Feb 2005 (UTC)

Wikipedia does not answer questions. You'd better go to the reference desk. I wish there were more "experts" on Wikipedia :-) JFW | T@lk 17:49, 7 Feb 2005 (UTC)

A lot of the things you mention may be mediated by endorphins, which are the natural ligands for the opioid receptors in the brain. Stimulation, stress and belief may lead to a release of these substances. JFW | T@lk 17:51, 7 Feb 2005 (UTC)

Alcohol

Alcohol doesn't count as a painkiller, does it? —The preceding unsigned comment was added by 207.200.116.198 (talk • contribs) .

Technically alcohol is an "outdated" painkiller, but it certainly does numb the perception of pain. --Thoric 15:48, 14 June 2006 (UTC)

Unreferenced

Needs one or more references for the content, added tag.--FloNight 21:26, 25 November 2005 (UTC)

The tag belongs on the article, not here. As a general rule, talk pages don't need to cite sources :-) (See Category:Articles lacking sources.)

chocolateboy 11:35, 30 November 2005 (UTC)

Over-prescription?

Doctors over-prescribing narcotics? There have been exceedingly few cases of such a thing. By far the problem is under-prescribing. Most doctors are afraid to prescribe anything stronger than Tylenol No. 3 (which contains codeine). Under-prescribing of narcotics to patients in severe pain (cancer, back/neck injury, major surgery) has become a far more serious problem than prescription narcotic addiction could ever be. It seems that the powers that be would far prefer a patient to suffer intense pain for the rest of their lives, and/or to suffer complications from over-use of NSAIDs (ulcers, internal bleeding, heart attacks, death) than to take a chance they might become addicted to a narcotic. In what sane world is suffering and death preferable to the chance of addiction? --Thoric 15:57, 14 June 2006 (UTC) Edit note -- pure narcotic formulations (namely Oxycontin) were the only narcotics that were specifically over-prescribed, and primarily to people who were already addicted to narcotics. I would go so far as to say that reduction in heroin use was proportional to increase in Oxycontin use. Most doctors under-prescribe narcotics, and instead over-prescribe NSAIDs. --Thoric 22:21, 14 June 2006 (UTC)

Thoric, I have no idea what you are basing your edits on. They contain value judgements (who says there is over- or underprescription?) At the moment they gloriously fail both WP:NPOV and WP:RS, and I have removed them until these policies can be satisfied.

You also reintroduced a weird little misplaced paragraph that wants us to know certain NSAIDs may increase risk for coronary artery disease. This fact should me mentioned in the relevant articles, not here, and with an academic reference (as opposed to a poorly researched news article). JFW | T@lk 22:55, 14 June 2006 (UTC)

I didn't add the paragraph blaming doctors for over-prescription. I only toned it down and pointed out that under-prescription has been a growing problem. The reintroduction of the news article link was an oversight. --Thoric 13:48, 15 June 2006 (UTC)

Just a comment on the part of the article that talks about addiction to "pure" narcotics. It says that Lortab and Vicodin are hydrocodone only. I don't think thats true. I know at least those two are hydrocodone/acetaminophen(APAP). 161.45.236.217 17:42, 2 November 2006 (UTC)Matt

A response to the last comment: Lortab and Vicodin are both (traditionally) 5/500 (5mg Hydrocodone, the narcotic, 500mg Tylenol). Whatever "blend" (or whatever) they are, they're still Hydrocodone "blends"... Hope this helps a bit...  :-) --JeffF

Copyvio

Somebody dumped this from the "Harvard Magazine" site. I cannot disagree with some points raised in that material, though. For example, physiotherapy, behavioral/relaxation techniques and surgery may be used to achieve analgesia. Perhaps we should expand the article to reflect this. JFW | T@lk 14:31, 17 July 2006 (UTC)

Atypical and/or adjuvant analgesics

I did some minor copyedits, but this section needs more edits relying upon subject-matter knowledge that I lack. Here are some suggestions.

Section heading. The section heading is awkward (see WP:MOS#Slashes and its subordinate section on "and/or"), and might not even need to use both adjectives. If "atypical analgesics" and "adjuvant analgesics" are synonyms, as the body text seems to imply, then use one of those terms in the heading and explain the alternate name in the body text. Thus, the section heading could be, simply, Adjuvant analgesics, and the body text could begin with "Adjuvant analgesics, also called atypical analgesics, ...". If those terms are not synonyms, then the heading could be, Atypical and adjuvant analgesics; however, there is no explicit reference to atypical analgesics in that section now, so additional editing would be needed to identify those drugs that are already included from that category, or to add them to the section, or to drop that adjective from the heading.

Run-on sentence. The first sentence is overly complex and appears to be serving two purposes: a list of drugs in one or both categories; and a description of their usage. So, it should be split up. For example, the revised wording could be, Adjuvant analgesics, also called atypical analgesics, include orphenadrine, cyclobenzaprine, scopolamine, atropine, gabapentin, first-generation antidepressants and other drugs possessing anticholinergic and/or antispasmodic properties. These drugs are used in many cases along with analgesics to potentiate centrally acting analgesics such as opioids when used against pain--especially of neuropathic origin--and to modulate the effects of many other types of analgesics by action in the parasympathetic nervous system.

Inconsistency. The first sentence about THC ascribes to it an "indisputably true benefit" that "may be" its superior anti-nauseant action. If we can say only "may be", then we can hardly describe that benefit as indisputable. Also, "indisputably true benefit" is redundant; "indisputable benefit" is sufficient.

I think there may be a couple of problems in the logic of the sentence structure in the Addiction section, too, but I'll stop here for now.

My 2¢ worth. --rich<Rich Janis 02:04, 27 July 2007 (UTC)>

NSAIDs

There are a number of fact tags in the NSAID/Paracetamol section regarding potential side-effects. These should all be listed, per FDA regulations in the US, on the product inserts. How does one cite these, specifically? siafu 22:51, 7 September 2007 (UTC)

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