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Gamma-rays vs. X-rays
I'd just like to point out that linear accelerators produce radiation by accelerating electrons and focussing them at a high-Z target. The resulting Bremmstrahhlung photons are technically x-rays. Gamma-rays are produced by radioactive decay of an unstable isotope, the most famous in the context of radiotherapy being Cobalt-60. —The preceding unsigned comment was added by 137.82.96.26 (talk) 05:17, 4 January 2007 (UTC).
- It sounds like you know far more about this than I do. Feel free to edit the article! InvictaHOG 19:55, 5 January 2007 (UTC)
"Stiffness"
Someone replaced "erection" with "stiffness" in the Symptoms section. I have changed the word back to "erection," since this is the legitimate, neutral term for erection of the penis. People, this is the prostate cancer page, we should be mature enough to have the word "erection" on it. "Stiffness" seems like something Borat would say, or akin to the slang "stiffie," and is not a good euphemism for "erection." It is what it is. The animal researchers call erections "flips," but I don't think laypeople would understand that word. I hope nobody reverts the word back. Whatever, there are thousands of words in the article, but this one matters some.--Dr.michael.benjamin 04:09, 2 March 2007 (UTC)
Carbs
I can't see any evidence that carbohydrates affect the likelyhood of getting prostate cancer. I'm removing that until someone provides cites. Novalis 14:54, 24 May 2007 (UTC)
Study: Pectin kills prostate cancer cells
“What this paper shows is that if you take human prostate cancer cells and add pectin, you can induce programmed cell death,” said Mohnen, a professor of biochemistry and molecular biology. “If you do the same with non-cancerous cells, cell death doesn’t occur.” [1] Brian Pearson 02:12, 21 August 2007 (UTC)
JCI article
doi:10.1172/JCI31791 reviews the biology and treatment of prostate cancer in this month's J Clin Invest. JFW | T@lk 15:47, 16 September 2007 (UTC)
bad link?
reference 21 points to http://tools.wikimedia.de/~magnus/makeref.php which is some sort of "reference-generator" :S Vancomycin (talk) 19:05, 17 December 2007 (UTC)
- I've replaced the reference with the journal article that the news article was referring to, the url should work. - Optigan13 (talk) 03:43, 18 December 2007 (UTC)
Contradictory information?
There seems to be some information that contradicts itself on this article.
Under "Etiology" the article says: "Other dietary factors that may increase prostate cancer risk include low intake of vitamin E (Vitamin E is found in green, leafy vegetables), omega-3 fatty acids (found in fatty fishes like salmon), and the mineral selenium. "
However under "Prevention" the article says: "Two dietary supplements, vitamin E and selenium, may help prevent prostate cancer when taken daily."
I am assuming under Etiology is should be decrease instead of increase?
OR
Is it saying "low intake" as in insufficient ammounts of vitamin E may increase risk of prostate cancer?
Either way the way its worded is a little confusing and my first impression is that this was a typo.
Thanks
Stvns78 (talk) 22:01, 12 January 2008 (UTC)
- "Low is used as in "insufficient." Because of the qualifiers here "insufficient" may incorrectly sound as if there is a known "sufficient" quantity. —Preceding unsigned comment added by 75.18.49.189 (talk) 17:19, 12 March 2008 (UTC)
NICE guideline
We should probably integrate some content from National Institute for Health and Clinical Excellence. Clinical guideline 58: Prostate cancer. London, 2008. JFW | T@lk 08:54, 29 February 2008 (UTC)
Diet
I've removed the following paragraphs:
===Diet=== There is now growing medical evidence for the effectiveness of diet in counteracting prostate cancer. Lycopene is a naturally occurring chemical found in tomatoes, watermelons, pink grapefruits, papaya, and guava (Gann, Peter H., Giovannucci, Edward L. p.14-15). Cooked tomatoes and tomato sauce are actually better than raw tomatoes because cooking them releases lycopene from their storage sites, changes the way our bodies absorb it, and affects the growth of prostate cancer cells. Next, we have cruciferous vegetables such as broccoli, cauliflower, cabbage, brussel sprouts, bok choy, and kale. This is because they contain sulforaphane, a compound that increases protein activity that cleans up the damage done by ingesting cancer-causing carcinogens (Gann, et al, p. 16-17). Polyphenols found in red wine and green tea have shown to prevent, slow, and kill the formation of cancer cells, as have isoflavones (genistein, daidzein, and equol) from soy-based foods. However, too much can neutralize its benefits (Alberts & Hess, p. 298). The "Western-style" diet is notorious for including a lot of fats and red meat. This kind of diet has long been associated with a high risk for many diseases and cancers. The previously cited report Nutrition and Prostate Cancer (Gann, et al) focuses on two issues of the "Western-style" diet: the type of fat and the cooking method. Substituting some fish for red meat is not only a "heart healthy" choice, but research shows that the omega-3 fatty acids in fish and fish oils decreases the risk of developing prostate cancer by 26 percent. Those who like to grill meat may want to switch to an alternate form of cooking. Charring left on meat off the grill has been linked to cancer-causing carcinogens. One dieting alternative, as reported in the article Cancer Proof Your Prostate by Matt Bean of Men’s Health Magazine, is a Mediterranean-style of diet. It states that the reason why Western European men have much lower prostate cancer rates than Americans do is because they eat decent amounts of garlic, pasta sauce, and scallions. In fact, those that eat more than 10 grams of garlic or scallions daily have a 50 percent lower risk of developing prostate cancer. 1. Moyad, Mark A. The ABC’s of Nutrition and Supplements for Prostate Cancer, Sleeping Bear Press, MI, USA, 2000. 2. Alberts, David S., Hess, Lisa M. Fundamentals of Cancer Prevention, Springer Publishing Company, Berlin, Germany, 2005, p. 277-283, 292-307. 3. Gann, Peter H., Giovannucci, Edward L. "Nutrition and Prostate Cancer," Prostate Cancer Foundation, 2005. 4. Bean, Matt. "Cancer Proof Your Prostate," Men’s Health, www.menshealth.com, Rodale Inc., 2007. Wells, Sara. "Hedonist’s Guide to Prostate Prevention," Men’s Health, www.menshealth.com, Rodale Inc., 2007.
There are a couple of issues. The sourcing is not adequate (Men's Health?) We should discuss lycopene, but we need to use better sources. There is a lot of published literature and even a few recent review articles on the subject (e.g. PMID 17893870, PMID 18006906). Let's use those. Also, this should be in the "Prevention" section, worked into the existing text there, and not in the "Treatment" section. Let's work on it here. MastCell Talk 05:38, 2 March 2008 (UTC)
- MastCell makes a good point here. Though there is some population data that certain dietary modifications can reduce the risk of developing cancer, no reliable data that I know of show that it can fight cancer. I try to work on the text for placing this in "Prevention" when I have a little more time. Djma12 (talk) 14:47, 2 March 2008 (UTC)
Recent reverts
Why were the sections reverted (see http://en.wikipedia.org/w/index.php?title=Prostate_cancer&diff=199887399&oldid=199105475) that started:
- "Computed tomography (CT) and magnetic resonance imaging (MRI) currently do not add any significant information in the assessment of possible lymph node metastases in patients with prostate cancer according to a meta-analysis."
and
- "In the hands of an experienced surgeon, robotic assisted laparoscopic prostatectomy (RALP) can reduce positive surgical margins when compared to radical retropubic prostatectomy (RRP) among patients with prostate cancer according to a retrospective study." [I think 'may reduce' might be better than 'can reduce']
reverted by user:orangemarlin for reasons of advsertisting. All that was done was report two medline abstracts. I do not see how this is advertising. Ok to restore these sections (at the same time fixing the links to PubMed using citeref)? Thanks - Badgettrg (talk) 21:00, 24 March 2008 (UTC)
- I think Orangemarlin was indeed worried about advertising. If we remove the URine tests and replace them with cite templates everything should be fine. JFW | T@lk 19:59, 25 March 2008 (UTC)
I had put the following on Finasteride:
A 2008 study found that finasteride reduces the of prostate cancer rate by 30%![1] [2]
For some reason, what I took to be important news was deleted. I am putting it back in.
Masturbation
Sorry guys, I can't find any serious peer-reviewed articles that state frequent masturbation has an effect on the risk of prostate cancer. Mostly, what I find in the most recent studies is that there is no effect. I deleted most of the paragraph, since much of the writing was related to a newspaper article. I ran a pubmed to see if anything came up (so to speak, I know, there are dozens of puns here), and all I could find was not much. OrangeMarlin Talk• Contributions 07:40, 18 June 2008 (UTC)
- I saw the above and looked at the original sources, then followed them up and found the study. Peer-reviewed, saying quite what the text had said. Then I looked at the article Orangemarlin had cited, calling it "the most recent studies," -- it's one study, issued shortly after the Australian study -- and it appears to confirm the Australian study, but the matter is a bit unclear, since, in the abstract, which is all I've read, two opposite conclusions seem to exist. There is also a reply by Giles to the later study in JAMA, which isn't abstracted, I'd have to get access to full text. The Giles study has attracted a lot of attention, to remove this wasn't proper. The issue isn't "masturbation," the issue is ejaculation frequency, and earlier studies had only focused on sexual intercourse, looking for evidence of infectious agents. One follow-up to the Giles study seems to criticize it for not considering the effect of oxytocin, which is a bit puzzling to me, since that would be a mechanism and not particularly relevant to the finding re frequency, perhaps the Giles article speculates about mechanism. I've replaced the material, including expanding what Orangemarlin inserted to make it more balanced. --Abd (talk) 14:11, 18 June 2008 (UTC)
Robotics
Insert non-formatted text here
As is true with the general trend of treatment discussions in the US, this article has a heavy slant toward RALP being a better treatment option. It may or or may not be and if it is, it's only after a rather steep learning curve. The data isn't ready for that yet. In addition to that, the perineal doesn't even get mentioned despite the fact it's still done, has no abdominal incisions, short catheter duration, etc etc etc. Intuitive has done a wonderful advertising job for their product and we don't need to serve for more free advertisement here. —Preceding unsigned comment added by Yourskeptic (talk • contribs) 12:24, 21 July 2008 (UTC)
Mistake in redirection ?
It looks like the redirection comment about HRPC is wrong (top of the article). ... I have no idea how to update this. 85.27.110.140 (talk) 01:43, 23 July 2008 (UTC)
Cannabinoids
Could something regarding the use of cannabinoids to treat prostate cancer be added to the article? Unfortunately there are no current treatments avaialble but numerous research has shown that cannabinoids can cause apoptosis. Particuarly this paper [2] - which states the following.
"Treatment with a cannabinoid (WIN55,212-2) resulted in a dose-dependent inhibition of cell growth and induction of apoptosis in cancer cells..... Based on these data we suggest that cannabinoid receptor agonists should be considered as novel agents for the management of prostate cancer". Also this paper from 1999.
Supposed (talk) 01:49, 24 July 2008 (UTC)
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