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The missing subtype?
I've found a bunch of sources that say there are six subtypes (L, N, P, Q, R, and T), and one source * that says there are seven, but does not list them! Does anyone know what this missing subtype is? Thanks much, delldot | talk 18:34, 22 April 2006 (UTC)
* Kim AH, Kerchner GA, and Choi DW. 2002. Blocking Excitotoxicity. Chapter 1 in: CNS Neuroproteciton. Marcoux FW and Choi DW, editors. Springer, New York. pp. 3 - 36.
- There are only five actually: L, T, N, P/Q, and R. Of course, there are 4 L-type channels and three T-type channels for a total of 10 channels total. At least, this is how many α-1 subunits there are. See Hille's book, any review, or: http://www.neuro.wustl.edu/neuromuscular/mother/chan.html#ca for examples. -Dpryan 06:31, 2 August 2006 (UTC)
Is the P/Q chanel just one channel or two?!?
- One gene->two channels. Q is an alternatively spliced form of P...so kind of one channel and kind of two, depending on how you define things. --Dpryan 19:23, 16 September 2006 (UTC)
Hasn't the nomenclature for voltage gated ion channels changed? Last thing I read L channels were now called Cav1.1-1.4, P channels are Cav 2.1, and N channels are Cav2.2, and so forth...
Classification of subtypes
Ideally, the clasifications of the channel subtypes on this page should be reorganized to reflect the functional differences. Unfortunatly, there hasn't been a review article writen about the functional differences that reflects the new (e.g. 1.1.3, etc) classification scheme. (source: pubmed search on 5/9/07) I don't think we can really fix this page until the literature sorts itself out. Too bad for people like me who are trying to learn it! Bakerstmd 19:16, 9 May 2007 (UTC)
- have you read this review: Annu. Rev. Cell Dev. Biol. 2000. 16:521–55. it is a long article, but it is very useful for VGCC. (he also wrote a review for VDNC's as well)
- I have added a Pharmacol Review reference from 2005 (see reference #1 in article), which appears to directly answer your question (see table 1 in ref). Boghog2 15:04, 20 May 2007 (UTC)
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- This page was last modified on 17 March 2008, at 05:24.
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