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Tetracaine
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| Systematic (IUPAC) name | |
| 2-(dimethylamino)ethyl 4-(butylamino)benzoate | |
| Identifiers | |
| CAS number | 136-47-0 (hydrochloride) |
| ATC code | C05 D04 N01 S01 |
| PubChem | |
| Chemical data | |
| Formula | C15H24N2O2 |
| Mol. mass | 264.363 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | 75.6 |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | Topical, Epidural, Spinal |
Tetracaine (INN, also known as amethocaine; trade name Pontocaine) is a potent local anesthetic of the ester group. It is mainly used topically, in ophthalmology and as an antipruritic, and has been used in spinal anesthesia.
In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptor) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely[1].
References
- ^ Györke, S., V. Lukyanenko, et al. Dual effects of tetracaine on spontaneous calcium release in rat ventricular myocytes. J Physiol 1997;500(Pt 2):297-309.
1. Györke, S., V. Lukyanenko, et al. Dual effects of tetracaine on spontaneous calcium release in rat ventricular myocytes. J Physiol 1997;500(Pt 2):297-309.
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Faisal Al-Otaibi
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Wikipedia content modification information:
- This page was last modified on 30 August 2008, at 23:15.
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