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| Thromboxane A2 | |
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| Identifiers | |
| CAS number | [57576-52-0] |
| PubChem | |
| MeSH | |
| Properties | |
| Molecular formula | C20H32O5 |
| Molar mass | 352.465 g/mol |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox references |
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Thromboxane A2 is a thromboxane. It is generated from prostaglandin H2 by thromboxane-A synthase. It is also a major component of blood clots. Aspirin irriversibly inhibits platelet cyclooxygenase preventing the formation of prostaglandin H2, and therefore Thromboxane A2. TXA2 is very unstable in aqueous solution, since it’s hydrolyzed within about 30s to the biologically inactive TXB2. Due to its very short half life, TXA2 primarily functions as an autocrine or paracrine mediator in the nearby tissues surrounding its site of production. Most work in TXA2 area is done with its synthetic analogs- U46619 & I-BOP.
Receptors that mediate TXA2 actions are thromboxane A2 receptors.The human TXA2 receptor (TP) is a typical G-protein coupled receptor (GPCR) with seven transmembrane segments.In humans, two TP receptors-TPα and TPβ has so far been cloned
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- This page was last modified on 7 August 2008, at 08:36.
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