Tolazoline

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Tolazoline
Systematic (IUPAC) name
2-benzyl-4,5-dihydro-1H-imidazole
Identifiers
CAS number 59-98-3
ATC code C04AB02 M02AX02
PubChem 5504
DrugBank APRD00170
Chemical data
Formula C10H12N2 
Mol. mass 160.216 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes IV

Tolazoline is a competitive α-adrenergic receptor antagonist. It is a vasodilator that is used to treat spasms of peripheral blood vessels (as in acrocyanosis).

It is also used in veterinary medicine to reverse xylazine-induced sedation.[1][2]

References

  1. ^ Boothe DM (2001). "Anticonvulsant drugs and analeptic agents", in Adams HR (ed.): Veterinary pharmacology and therapeutics. Ames: Iowa State University Press, pp. 378–9. ISBN 0-8138-1743-9.  Retrieved September 8, 2008 through Google Book Search.
  2. ^ Hall LW, Clarke KW, Trim CM (2001). "Principles of sedation, analgesia and premedication", Veterinary anaesthesia. Philadelphia: W.B. Saunders, pp. 90–1. ISBN 0-7020-2035-4.  Retrieved September 8, 2008 through Google Book Search.


Tablets  This pharmacology-related article is a stub. You can help Wikipedia by expanding it.
v • d • e
Adrenergic antagonists
α
Non-selective α
reversible (Phentolamine) · irreversible (Phenoxybenzamine)
Ungrouped
Tolazoline
β
β1 selective
(cardioselective)
Mixed α1/β
Indirect
tyrosine hydroxylase inhibitor (Metirosine) · vesicle storage inhibitor (Reserpine) · neurotransmitter release blocker (Guanethidine, Bretylium)
v • d • e
Peripheral vasodilators (C04)
Imidazoline derivatives/
Alpha blockers
Niacin and derivatives
Purine derivatives
Ergot alkaloids
Other peripheral vasodilators
v • d • e
Topical products for joint and muscular pain (M02)
Anti-inflammatory preparations,
non-steroids
Acetic acid derivatives
Other
Other
Tolazoline - Dimethyl sulfoxide

Wikipedia content modification information:

  • This page was last modified on 3 October 2008, at 13:15.

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