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Tolterodine
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| Systematic (IUPAC) name | |
| 2-(3-(diisopropylamino)-1- phenylpropyl)-4-methylphenol | |
| Identifiers | |
| CAS number | |
| ATC code | G04 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C22H31NO |
| Mol. mass | 325.488 g/mol |
| Pharmacokinetic data | |
| Bioavailability | 77% |
| Protein binding | Approximately 96.3%. |
| Metabolism | ? |
| Half life | 1.9-3.7 hours |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence. It is sold under the trade names Detrol and Detrusitol.
Pharmacology
Tolterodine acts on M2 and M3 subtypes of muscarinic receptors whereas most antimuscarinic treatments for overactive bladder only act on M3 receptors making them more selective.
Tolterodine, although it acts on two types of receptors, has fewer side effects than other antimuscarinics eg. oxybutynin (which is selective for M3 only) as tolterodine targets the bladder more than other areas of the body. This means that less drug needs to be given daily (due to efficient targeting of the bladder) and so there are fewer side effects.
Side effects
Known Side Effects:
- Hyposalivation (Dry mouth)
- Decreased gastric motility (Upset stomach)
- Headache
- Constipation
- Dry eyes
- Sleepiness
Reports of Patients’ Experiences Since Detrol Became Available:
The following reactions have been reported in patients who have taken Detrol since it has become available:
- Allergic reactions including swelling
- Rapid heartbeat or abnormal heartbeat
- Accumulation of fluid in the arms and legs
- Hallucinations
Contraindications:
Not to be used in patients with Myasthenia Gravis and Angle Closure Glaucoma
External links
- Detrol - FDA factsheet
- Tolterodine
- Tolterodine (patient information)
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Wikipedia content modification information:
- This page was last modified on 15 June 2008, at 02:26.
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