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Torasemide
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| Systematic (IUPAC) name | |
| 1-[4-(3-methylphenyl) aminopyridin-3-yl] sulfonyl-3-propan-2-yl-urea | |
| Identifiers | |
| CAS number | |
| ATC code | C03 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C16H20N4O3S |
| Mol. mass | 348.421 g/mol |
| SMILES | & |
| Pharmacokinetic data | |
| Bioavailability | 80-90% |
| Protein binding | Highly bound (>99%). |
| Metabolism | Hepatic (80%) |
| Half life | 3.5 hours; Cirrhosis: 7-8 hours |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
C(US) |
| Legal status | |
| Routes | Oral, IV |
Torasemide (rINN) or torsemide (USAN) is a pyridine-sulfonylurea type loop diuretic mainly used in the management of edema associated with congestive heart failure. It is also used at low doses for the management of hypertension. It is marketed under the brand name Demadex.
Compared to other loop diuretics, torasemide has a more prolonged diuretic effect than equipotent doses of furosemide and relatively decreased potassium-loss. There is no evidence of torasemide-induced ototoxicity demonstrated in humans [1].
References
- ^ Dunn CJ, Fitton A, Brogden RN (January 1995). "Torasemide. An update of its pharmacological properties and therapeutic efficacy". Drugs 49 (1): 121–42. PMID 7705212.
External links
- Medlineplus drug information: Torsemide (Systemic) – information from USP DI Advice for the Patient
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Wikipedia content modification information:
- This page was last modified on 30 September 2008, at 13:42.
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