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| Structure of corticosteroid-binding globulin in complex with cortisol. | |
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Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6, also Corticosteroid-Binding Globulin or Transcortin
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| Identifiers | |
| Symbol | SERPINA6 |
| Alt. Symbols | CBG |
| Entrez | 866 |
| HUGO | 1540 |
| OMIM | 122500 |
| RefSeq | NM_001750 |
| UniProt | P08185 |
| Other data | |
| Locus | Chr. 14 q32.1 |
Transcortin, also corticosteroid-binding globulin or CBG, is officially called serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6.
It is an alpha-globulin.
Contents |
Binding
Transcortin binds several steroid hormones:
- Cortisol. Approximately 75% of the cortisol in circulation is bound to this plasma protein. (The rest is bound to serum albumin.) The cortisol is thought to be biologically active only when it is not bound to transcortin.
- Aldosterone. 60% of the aldosterone in blood is bound to this plasma protein.
Production
Transcortin is produced by the liver and is regulated by estrogens. Therefore, plasma transcortin levels increase during pregnancy, and are decreased in cirrhosis.
See also
External links
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Wikipedia content modification information:
- This page was last modified on 27 September 2008, at 18:23.
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