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U-89843A
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| Systematic (IUPAC) name | |
| 6,7-dimethyl-2,4-dipyrrolidin-1-ylpyrrolo[3,2-e]pyrimidine | |
| Identifiers | |
| CAS number | |
| ATC code | ? |
| PubChem | |
| Chemical data | |
| Formula | C16H23N5 |
| Mol. mass | 285.387 g/mol |
| SMILES | & |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status |
Legal |
| Routes | ? |
U-89843A (PNU-89843) is a sedative drug which acts as an agonist at GABAA receptors, specifically acting as a positive allosteric modulator selective for the α1, α3 and α6 subtypes.[1] It has sedative effects in animals but without causing ataxia, and also acts as an antioxidant and may have neuroprotective effects.[2]
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References
- ^ Im HK, Im WB, Pregenzer JF, Carter DB, Hamilton BJ. U-89843A is a novel allosteric modulator of gamma-aminobutyric acidA receptors. Journal of Pharmacology and Experimental Therapeutics. 1995 Dec;275(3):1390-5. PMID 8531107
- ^ Bundy GL, Ayer DE, Banitt LS, Belonga KL, Mizsak SA, Palmer JR, Tustin JM, Chin JE, Hall ED, Linseman KL, et al. Synthesis of novel 2,4-diaminopyrrolo-[2,3-d]pyrimidines with antioxidant, neuroprotective, and antiasthma activity. Journal of Medicinal Chemistry. 1995 Oct 13;38(21):4161-3. PMID 7473542
Wikipedia content modification information:
- This page was last modified on 16 July 2008, at 08:29.
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