UDP-glucuronosyltransferase

This MedLibrary.org supplementary page on UDP-glucuronosyltransferase is provided directly from the open source Wikipedia as a service to our readers. Please see the note below on authorship of this content, as well as the Wikipedia usage guidelines. To search for other content from our encyclopedia supplement, please use the form below:

Related Sponsors

BM Pharmacy Generic pharmaceuticals at unbeatable prices. Insomnia, men's health, hair health, pain control. bmpharmacy.com
Online Pharmacy Carisoprodol, tadalafil, sildenafil, vardenafil and more... xlpharmacy.com
MedBasket.com Discreet. Inexpensive. Fast shipping. Great selection. What more can we say? medbasket.com
Frugalmed 2000 reasons to shop with us first. frugalmed.com
Ads by Tiva

Glucuronosyltransferase
Identifiers
Symbol UGT1A1
Entrez 54658
HUGO 12530
OMIM 191740
RefSeq NM_000463
UniProt P22309
Other data
EC number 2.4.1.17
Locus Chr. 2 q37

Uridine 5'-diphospho-glucuronosyltransferase (UDP-glucuronosyltransferase, UGT) is a glycosyltransferase (EC 2.4.1.17) that catalyzes the glucuronidation reaction.[1]

Alternative names:

  • glucuronyltransferase

Contents

Function

This reaction involves the addition of sugars to lipids and other apolar xenobiotics and is an important step in the body's elimination of foreign substances (such as drugs and medications) as well as endogenous substances (including endogenous toxins). UGT is present in humans, other animals, plants, and bacteria.

The glucuronidation reaction consists of the transfer of the glucuronosyl group from uridine 5'-diphospho-glucuronic acid (UDPGA) to substrate molecules that contain oxygen, nitrogen, sulfur or carboxyl functional groups.[2] The resulting glucuronide is more polar (e.g. hydrophilic) and more easily excreted than the substrate molecule. The product solubility in blood is increased allowing it to be eliminated from the body by the kidneys.

Diseases

A deficiency in the bilirubin specific form of glucuronosyltransferase is thought to be the cause of Gilbert's syndrome, which is characterized by hyperbilirubinemia.

It is also associated with Crigler-Najjar syndrome, a more serious disorder where the enzyme's activity is either completely absent (Crigler-Najjar syndrome type I) or less than 10% of normal (type II).

Genes

External links

References

  1. ^ King C, Rios G, Green M, Tephly T (2000). "UDP-glucuronosyltransferases". Curr Drug Metab 1 (2): 143–61. doi:10.2174/1389200003339171. PMID 11465080. 
  2. ^ Bock K, Köhle C. "UDP-glucuronosyltransferase 1A6: structural, functional, and regulatory aspects". Methods Enzymol 400: 57–75. PMID 16399343. 
v • d • e
Transferases: glycosyltransferases (EC 2.4)
2.4.1 - Hexosyltransferases
Glucuronosyltransferase
2.4.2 - Pentosyltransferases
Other

Wikipedia content modification information:

  • This page was last modified on 15 July 2008, at 10:02.

Wikipedia Authorship and Review

Wikipedia content provided here is not reviewed directly by MedLibrary.org. Wikipedia content is authored by an open community of volunteers and is not produced by or in any way affiliated with MedLibrary.org.

Wikipedia Usage Guidelines

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article on "UDP-glucuronosyltransferase".

The URL for this specific entry is:

All Wikipedia text is available under the terms of the GNU Free Documentation License. (See Copyrights for details). Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc.