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Nerve: Vagus nerve
Plan of upper portions of glossopharyngeal, vagus, and accessory nerves.
Course and distribution of the glossopharyngeal, vagus, and accessory nerves.
Latin	nervus vagus
Gray's	subject #205 910
Innervates	Levator veli palatini, Salpingopharyngeus, Palatoglossus, Palatopharyngeus, Superior pharyngeal constrictor, Middle pharyngeal constrictor, Inferior pharyngeal constrictor, viscera
MeSH	Vagus+Nerve

The vagus nerve (pronounced /ˈveɪˌgəs/) (VĀ-gəs) (also called pneumogastric nerve or cranial nerve X) is the tenth of twelve paired cranial nerves, and is the only nerve that starts in the brainstem (within the medulla oblongata) and extends, through the jugular foramen, down below the head, to the neck, chest and abdomen, where it contributes to the innervation of the viscera.

The medieval Latin word vagus means literally "Wandering" (the words vagrant, vagabond, and vague come from the same root). Sometimes the branches are spoken of in the plural and are thus called vagi (/ˈveɪˌgаɪ/) (VĀ-gī). The vagus is also called the pneumogastric nerve since it innervates both the lungs and the stomach.

Contents 1 Branches 2 Innervation 3 The vagus nerve and the heart 4 Medical treatment involving the vagus nerve 5 Physical and emotional effects 6 Effects of vagus nerve lesions 7 Additional images 8 References 9 External links

Branches

• Auricular nerve
• Pharyngeal nerve
• Superior laryngeal nerve
• Superior cervical cardiac branches of vagus nerve
• Inferior cervical cardiac branch
• Recurrent laryngeal nerve
• Thoracic cardiac branches
• Branches to the pulmonary plexus
• Branches to the esophageal plexus
• Anterior vagal trunk
• Posterior vagal trunk

Innervation

Both right and left vagus nerves descend from the spinal cord in the carotid sheath, lateral to the carotid artery.

The right vagus nerve gives rise to the right recurrent laryngeal nerve which hooks around the right subclavian artery and ascends into the neck between the trachea and esophagus. The right vagus then crosses anteriorly to the right subclavian artery and runs posterior to the superior vena cava and descends posterior to the right main bronchus and contributes to cardiac, pulmonary and esophageal plexuses. It forms the posterior vagal trunk at lower part of esophagus and enters diaphragm through esophageal hiatus.

The left vagus nerve enters the thorax between left common carotid artery and left subclavian artery and descends on the aortic arch. It gives rise to the left recurrent laryngeal nerve which hooks around the aortic arch to the left of the ligamentum arteriosum and ascends between the trachea and esophagus. The left vagus further gives off thoracic cardiac branches, breaks up into pulmonary plexus, continues into the esophageal plexus and enters the abdomen as the anterior vagal trunk in the esophageal hiatus of the diaphragm.

The vagus nerve supplies motor parasympathetic fibers to all the organs except the suprarenal (adrenal) glands, from the neck down to the second segment of the transverse colon. The vagus also controls a few skeletal muscles, namely:

• Cricothyroid muscle
• Levator veli palatini muscle
• Salpingopharyngeus muscle
• Palatoglossus muscle
• Palatopharyngeus muscle
• Superior, middle and inferior pharyngeal constrictors
• Muscles of the larynx (speech).

This means that the vagus nerve is responsible for such varied tasks as heart rate, gastrointestinal peristalsis, sweating, and quite a few muscle movements in the mouth, including speech (via the recurrent laryngeal nerve) and keeping the larynx open for breathing. It also receives some sensation from the outer ear, via the Auricular branch (also known as Alderman's nerve) and part of the meninges.

The vagus nerve and the heart

Parasympathetic innervation of the heart is mediated by the vagus nerve. The right vagus innervates the sinoatrial node. Parasympathetic hyperstimulation predisposes those affected to bradyarrhythmias. The left vagus when hyperstimulated predisposes the heart to atrioventricular (AV) blocks.

At this location Otto Loewi first proved that nerves secrete substances called neurotransmitters which have effects on receptors in target tissues. Loewi described the substance released by the vagus nerve as vagusstoff, which was later found to be acetylcholine.

The vagus nerve has three associated nuclei, the dorsal motor nucleus, the nucleus ambiguus and the solitary nucleus.

Drugs that inhibit the muscarinic cholinergic receptor (anticholinergics) such as atropine and scopolamine are called vagolytic because they inhibit the action of the vagus nerve on the heart, gastrointestinal tract and other organs. Anticholinergic drugs increase heart rate and are used to treat bradycardia (slow heart rate) and asystole, which is when the heart has no electrical activity. Anticholinergic drugs relax the detrusor muscle and cause constipation which again involves the vagus nerve.

Bulimics and anorexics have high vagal activity which is associated with the arrhythmias seen in these patients.^{citation needed}

Medical treatment involving the vagus nerve

Vagus nerve stimulation (VNS) therapy using a pacemaker-like device implanted in the chest is a treatment used since 1997 to control seizures in epilepsy patients and has recently been approved for treating drug-resistant cases of clinical depression.^[1] A convenient, non-invasive VNS device that stimulates an afferent branch of the vagus nerve is also being developed and will soon undergo trials.

A degree of intermittent VNS can be achieved by daily breathing exercises (for example, Pranayama) over a period of several weeks. In some patients, such proactive relaxation exercises have been found to correlate with lower blood pressure and lower heart rate and more stable moods.^{citation needed} The Valsalva maneuver may activate the vagus nerve and is a "natural" way to achieve the same effect in some patients. Patients with atrial fibrillation, supraventricular tachycardia and other illnesses may be trained to perform the valsalva maneuver (or find it for themselves).

Vagus nerve blocking (VBLOC) therapy, similar to VNS but only used during the day, has caused 31 obese participants in a six month open label trial involving three medical centers in Australia, Mexico and Norway to loose an average of nearly 15 percent of their excess weight. A one year 300 participant double blind phase II trial has begun. Mayo Clinic (2008, June 28). Device Blocking Stomach Nerve Signals Shows Promise in Obesity.

Vagotomy (cutting of the vagus nerve) is a now-obsolete therapy that was performed for peptic ulcer disease. Vagotomy is currently being researched as a less invasive alternative weight loss procedure to gastric bypass surgery^[2]. The procedure curbs the feeling of hunger and is sometimes performed in conjunction with putting bands on patients' stomachs, resulting in average weight loss of 43% at six months with diet and exercise^[3]. Five pencil-sized scars are the result of the procedure.

See also:

• Porphyria This rare disorder can cause seizures and damage to the vagal nerve. Diagnosis, in some cases, may require DNA testing.

Physical and emotional effects

Activation of the vagus nerve typically leads to a reduction in heart rate, blood pressure, or both. This occurs commonly in the setting of gastrointestinal illness such as viral gastroenteritis or acute cholecystitis, or in response to other stimuli, including carotid sinus massage, Valsalva maneuver, or pain from any cause, particularly having blood drawn. When the circulatory changes are great enough, vasovagal syncope results. Relative dehydration tends to amplify these responses.

Excessive activation of the vagal nerve during emotional stress, which is a parasympathetic overcompensation of a strong sympathetic nervous system response associated with stress, can also cause vasovagal syncope because of a sudden drop in blood pressure and heart rate. Vasovagal syncope affects young children and women more often. It can also lead to temporary loss of bladder control under moments of extreme fear.

Research has shown that women who have complete transection of the spinal cord can experience orgasms through the vagus nerve, which can go from the uterus, cervix and probably the vagina to the brain.[1]^[4]

Effects of vagus nerve lesions

The patient complains of hoarse voice, difficulty in swallowing (dysphagia) and choking when drinking fluid. There is also loss of gag reflex. Uvula deviates away from the side of lesion and there is failure of palate elevation.

Additional images

Section of the neck at about the level of the sixth cervical vertebra.	Transverse section of thorax, showing relations of pulmonary artery.	The arch of the aorta, and its branches.	Dura mater and its processes exposed by removing part of the right half of the skull, and the brain.
The tracheobronchial lymph glands.	Section of the medulla oblongata at about the middle of the olive.	Hind- and mid-brains; postero-lateral view.	Upper part of medulla spinalis and hind- and mid-brains; posterior aspect, exposed in situ.
The right sympathetic chain and its connections with the thoracic, abdominal, and pelvic plexuses.	The celiac ganglia with the sympathetic plexuses of the abdominal viscera radiating from the ganglia.	The position and relation of the esophagus in the cervical region and in the posterior mediastinum. Seen from behind.	The thyroid gland and its relations.
The thymus of a full-term fetus, exposed in situ.

References

1. ^ Nemeroff C, Mayberg H, Krahl S, McNamara J, Frazer A, Henry T, George M, Charney D, Brannan S (2006). "VNS therapy in treatment-resistant depression: clinical evidence and putative neurobiological mechanisms.". Neuropsychopharmacology 31 (7): 1345–55. doi:10.1038/sj.npp.1301082. PMID 16641939.  link
2. ^ Ulcer surgery may help treat obesity - Diet and nutrition - MSNBC.com
3. ^ http://www.cnn.com/2007/HEALTH/conditions/07/09/obesity.nerve.ap/index.html
4. ^ Komisaruk, B.R, Whipple, B., Crawford, A., Grimes, S., Liu, W-C., Kalin, A., & Mosier, K. (2004). "Brain activation during vaginocervical self-stimulation and orgasm in women with complete spinal cord injury: fMRI evidence of mediation by the Vagus nerves.".  link

External links

• MedEd at Loyola grossanatomy/h_n/cn/cn1/cn10.htm
• Cranial Nerves at Yale 10-1
• Human anatomy at Dartmouth figures/chapter_24/24-7.HTM
• Norman/Georgetown cranialnerves (X)

v • d • e Nerves of head and neck: the cranial nerves and nuclei olfactory (AON->I) olfactory bulb - olfactory tract optic (LGN->II) optic chiasm - optic tract oculomotor (ON,EWN->III) superior branch (parasympathetic root of ciliary ganglion/ciliary ganglion) - inferior branch trochlear (TN->IV) no significant branches trigeminal (PSN,TSN,MN,TMN->V) trigeminal ganglion • ophthalmic • maxillary • mandibular abducens (AN->VI) no significant branches facial (FMN,SN,SSN->VII) near origin nervus intermedius • geniculate inside facial canal greater petrosal (pterygopalatine ganglion) - nerve to the stapedius - chorda tympani (lingual nerve, submandibular ganglion) at stylomastoid foramen posterior auricular - suprahyoid (digastric, stylohyoid) - parotid plexus (temporal, zygomatic, buccal, mandibular, cervical) vestibulocochlear (VN,CN->VIII) cochlear (striae medullares, lateral lemniscus) • vestibular (Scarpa's ganglion) glossopharyngeal (NA,ISN,SN->IX) before jugular fossa ganglia (superior, inferior) after jugular fossa tympanic (tympanic plexus, lesser petrosal, otic ganglion) • stylopharyngeal branch • pharyngeal branches • tonsillar branches • lingual branches • carotid sinus vagus (NA,DNVN,SN->X) before jugular fossa ganglia (superior, inferior) after jugular fossa meningeal branch - auricular branch neck pharyngeal branch (pharyngeal plexus) - superior laryngeal (external, internal) - recurrent laryngeal (inferior) - superior cervical cardiac thorax inferior cardiac - pulmonary - vagal trunks (anterior, posterior) abdomen celiac - renal - hepatic - anterior gastric - posterior gastric accessory (NA,SAN->XI) cranial - spinal hypoglossal (HN->XII) lingual branches

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